ID   CISD2_DROPS             Reviewed;         132 AA.
AC   Q29BX8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=CDGSH iron-sulfur domain-containing protein 2 homolog;
GN   Name=Cisd2 {ECO:0000250|UniProtKB:Q9VAM6}; ORFNames=GA13095;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CISD protein family. CISD2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM000070; EAL26868.2; -; Genomic_DNA.
DR   RefSeq; XP_001357734.2; XM_001357697.3.
DR   AlphaFoldDB; Q29BX8; -.
DR   SMR; Q29BX8; -.
DR   STRING; 7237.FBpp0283181; -.
DR   EnsemblMetazoa; FBtr0284743; FBpp0283181; FBgn0073133.
DR   GeneID; 4800463; -.
DR   KEGG; dpo:Dpse_GA13095; -.
DR   eggNOG; KOG3461; Eukaryota.
DR   HOGENOM; CLU_132293_1_0_1; -.
DR   InParanoid; Q29BX8; -.
DR   OMA; VVDMIDI; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0073133; Expressed in insect adult head and 2 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR   Gene3D; 3.40.5.90; -; 1.
DR   InterPro; IPR045131; CISD1/2.
DR   InterPro; IPR018967; FeS-contain_CDGSH-typ.
DR   InterPro; IPR019610; FeS-contain_mitoNEET_N.
DR   InterPro; IPR042216; MitoNEET_CISD.
DR   PANTHER; PTHR13680; PTHR13680; 1.
DR   Pfam; PF10660; MitoNEET_N; 1.
DR   Pfam; PF09360; zf-CDGSH; 1.
DR   SMART; SM00704; ZnF_CDGSH; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; Endoplasmic reticulum; Iron; Iron-sulfur; Membrane; Metal-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..132
FT                   /note="CDGSH iron-sulfur domain-containing protein 2
FT                   homolog"
FT                   /id="PRO_0000316011"
FT   TOPO_DOM        1..35
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..132
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   BINDING         98
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
FT   BINDING         100
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
FT   BINDING         109
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
FT   BINDING         113
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   132 AA;  14407 MW;  0AE1A356B5E79A73 CRC64;
     MEPISHVVKS SLPNYLSSLP IPDSFGGWFK LSFKDWLALI PPTVVVAGLG YTTYLAFCPA
     ARCAGKDSGR CNSSIRKNEA KVVTMVDVED IAGQAAFCRC WKTKNWPYCD GSHGEHNKQT
     GDNVGPVVVK KK