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CISD2_DROSI
ID   CISD2_DROSI             Reviewed;         133 AA.
AC   B4QZI8;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=CDGSH iron-sulfur domain-containing protein 2 homolog;
GN   Name=Cisd2 {ECO:0000250|UniProtKB:Q9VAM6}; ORFNames=GD17906;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CISD protein family. CISD2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM000364; EDX14826.1; -; Genomic_DNA.
DR   RefSeq; XP_002105323.1; XM_002105287.2.
DR   AlphaFoldDB; B4QZI8; -.
DR   SMR; B4QZI8; -.
DR   STRING; 7240.B4QZI8; -.
DR   EnsemblMetazoa; FBtr0217816; FBpp0216308; FBgn0189452.
DR   GeneID; 6730030; -.
DR   HOGENOM; CLU_132293_1_0_1; -.
DR   OMA; PKCDGSH; -.
DR   PhylomeDB; B4QZI8; -.
DR   Proteomes; UP000000304; Chromosome 3r.
DR   Bgee; FBgn0189452; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007568; P:aging; IEA:EnsemblMetazoa.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0006839; P:mitochondrial transport; IEA:EnsemblMetazoa.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR   Gene3D; 3.40.5.90; -; 1.
DR   InterPro; IPR045131; CISD1/2.
DR   InterPro; IPR018967; FeS-contain_CDGSH-typ.
DR   InterPro; IPR019610; FeS-contain_mitoNEET_N.
DR   InterPro; IPR042216; MitoNEET_CISD.
DR   PANTHER; PTHR13680; PTHR13680; 1.
DR   Pfam; PF10660; MitoNEET_N; 1.
DR   Pfam; PF09360; zf-CDGSH; 1.
DR   SMART; SM00704; ZnF_CDGSH; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; Endoplasmic reticulum; Iron; Iron-sulfur; Membrane; Metal-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..133
FT                   /note="CDGSH iron-sulfur domain-containing protein 2
FT                   homolog"
FT                   /id="PRO_0000392029"
FT   TOPO_DOM        1..35
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   BINDING         100
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
FT   BINDING         102
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
FT   BINDING         111
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
FT   BINDING         115
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   133 AA;  14639 MW;  07BCD63B269F7A0E CRC64;
     MEPISHLVKS SLPNYLSSLP VPDSIGGWFK LSFKDWLALI PPTVVVAGIG YTAYLAYCPA
     ARASCSAKIS GRCNNQIRKN EPKVVDMIDV EDIAEKAAFC RCWKTKNWPY CDGSHGEHNK
     QTGDNVGPIV IKK
 
 
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