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CISD2_DROWI
ID   CISD2_DROWI             Reviewed;         134 AA.
AC   B4NFN4;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=CDGSH iron-sulfur domain-containing protein 2 homolog;
GN   Name=Cisd2 {ECO:0000250|UniProtKB:Q9VAM6}; ORFNames=GK22673;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Single-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CISD protein family. CISD2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CH964251; EDW83101.1; -; Genomic_DNA.
DR   RefSeq; XP_002072115.1; XM_002072079.2.
DR   AlphaFoldDB; B4NFN4; -.
DR   SMR; B4NFN4; -.
DR   STRING; 7260.FBpp0251816; -.
DR   EnsemblMetazoa; FBtr0253324; FBpp0251816; FBgn0224650.
DR   GeneID; 6649793; -.
DR   KEGG; dwi:6649793; -.
DR   eggNOG; KOG3461; Eukaryota.
DR   HOGENOM; CLU_132293_1_0_1; -.
DR   InParanoid; B4NFN4; -.
DR   OMA; VVDMIDI; -.
DR   OrthoDB; 1393750at2759; -.
DR   PhylomeDB; B4NFN4; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR   Gene3D; 3.40.5.90; -; 1.
DR   InterPro; IPR045131; CISD1/2.
DR   InterPro; IPR018967; FeS-contain_CDGSH-typ.
DR   InterPro; IPR019610; FeS-contain_mitoNEET_N.
DR   InterPro; IPR042216; MitoNEET_CISD.
DR   PANTHER; PTHR13680; PTHR13680; 1.
DR   Pfam; PF10660; MitoNEET_N; 1.
DR   Pfam; PF09360; zf-CDGSH; 1.
DR   SMART; SM00704; ZnF_CDGSH; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; Endoplasmic reticulum; Iron; Iron-sulfur; Membrane; Metal-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..134
FT                   /note="CDGSH iron-sulfur domain-containing protein 2
FT                   homolog"
FT                   /id="PRO_0000392031"
FT   TOPO_DOM        1..35
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   BINDING         101
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
FT   BINDING         103
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
FT   BINDING         112
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
FT   BINDING         116
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   134 AA;  14822 MW;  A3B386648A314337 CRC64;
     MESLSHLVKS TLPNYLSNLP VPDTLGGWFK LSFKDWLALI PPTVVVAGIG YTGYLAFCPA
     AQDRCSAKKN SGRCNNLIRK HEAKVVDMID VEDIAEKAAF CRCWKTKNWP YCDGSHGEHN
     KQTGDNVGPV VVKK
 
 
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