CISD2_TRIAD
ID CISD2_TRIAD Reviewed; 140 AA.
AC B3RML8;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=CDGSH iron-sulfur domain-containing protein 2 homolog;
GN ORFNames=TRIADDRAFT_21706;
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Trichoplacidae; Trichoplax.
OX NCBI_TaxID=10228;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999;
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000250};
CC Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CISD protein family. CISD2 subfamily.
CC {ECO:0000305}.
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DR EMBL; DS985242; EDV27872.1; -; Genomic_DNA.
DR RefSeq; XP_002109706.1; XM_002109670.1.
DR AlphaFoldDB; B3RML8; -.
DR SMR; B3RML8; -.
DR STRING; 10228.TriadP21706; -.
DR EnsemblMetazoa; TriadT21706; TriadP21706; TriadG21706.
DR GeneID; 6750921; -.
DR KEGG; tad:TRIADDRAFT_21706; -.
DR CTD; 6750921; -.
DR eggNOG; KOG3461; Eukaryota.
DR HOGENOM; CLU_132293_1_0_1; -.
DR InParanoid; B3RML8; -.
DR OMA; VVDMIDI; -.
DR OrthoDB; 1393750at2759; -.
DR PhylomeDB; B3RML8; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR Gene3D; 3.40.5.90; -; 1.
DR InterPro; IPR045131; CISD1/2.
DR InterPro; IPR018967; FeS-contain_CDGSH-typ.
DR InterPro; IPR019610; FeS-contain_mitoNEET_N.
DR InterPro; IPR042216; MitoNEET_CISD.
DR PANTHER; PTHR13680; PTHR13680; 1.
DR Pfam; PF10660; MitoNEET_N; 1.
DR Pfam; PF09360; zf-CDGSH; 1.
DR SMART; SM00704; ZnF_CDGSH; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; Endoplasmic reticulum; Iron; Iron-sulfur; Membrane; Metal-binding;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..140
FT /note="CDGSH iron-sulfur domain-containing protein 2
FT homolog"
FT /id="PRO_0000392033"
FT TOPO_DOM 1..35
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT BINDING 104
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 106
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 115
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
FT BINDING 119
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000250"
SQ SEQUENCE 140 AA; 15597 MW; 19ACC71165C460A1 CRC64;
MEAIAKLIKV QLPNYLQKLP VPSSLSGFAE LSPSDAIAVV FPFAVVSWLI GYSTYKFFQP
KAVELPPSPK AKDTNCVNKC IDKTCKKVVH TVDIEDVGEK LVFCRCWRSK KFPYCDGSHN
NHNEQEQDNV GPLIVKGKAN
