ID   CISH_BOVIN              Reviewed;         254 AA.
AC   Q2HJ53;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Cytokine-inducible SH2-containing protein;
DE            Short=CIS;
GN   Name=CISH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: SOCS family proteins form part of a classical negative
CC       feedback system that regulates cytokine signal transduction. CIS is
CC       involved in the negative regulation of cytokines that signal through
CC       the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin
CC       3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its
CC       tyrosine phosphorylation (By similarity). May be a substrate
CC       recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box
CC       protein) E3 ubiquitin-protein ligase complex which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Stably associated with the tyrosine-phosphorylated IL3
CC       receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR).
CC       {ECO:0000250}.
CC   -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC       BC complex, an adapter module in different E3 ubiquitin ligase
CC       complexes. {ECO:0000250}.
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DR   EMBL; BC113307; AAI13308.1; -; mRNA.
DR   RefSeq; NP_001040051.1; NM_001046586.1.
DR   AlphaFoldDB; Q2HJ53; -.
DR   SMR; Q2HJ53; -.
DR   STRING; 9913.ENSBTAP00000030624; -.
DR   PaxDb; Q2HJ53; -.
DR   PRIDE; Q2HJ53; -.
DR   Ensembl; ENSBTAT00000030652; ENSBTAP00000030624; ENSBTAG00000022622.
DR   GeneID; 616753; -.
DR   KEGG; bta:616753; -.
DR   CTD; 1154; -.
DR   VEuPathDB; HostDB:ENSBTAG00000022622; -.
DR   VGNC; VGNC:27374; CISH.
DR   eggNOG; KOG4566; Eukaryota.
DR   GeneTree; ENSGT00940000157392; -.
DR   HOGENOM; CLU_079452_4_1_1; -.
DR   InParanoid; Q2HJ53; -.
DR   OMA; LCVQGPH; -.
DR   OrthoDB; 1135696at2759; -.
DR   TreeFam; TF321368; -.
DR   Reactome; R-BTA-8951664; Neddylation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000022622; Expressed in semitendinosus and 102 other tissues.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   CDD; cd10718; SH2_CIS; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR028425; CIS.
DR   InterPro; IPR035887; CIS_SH2.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155:SF9; PTHR10155:SF9; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF158235; SSF158235; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   2: Evidence at transcript level;
KW   Growth regulation; Reference proteome; SH2 domain;
KW   Signal transduction inhibitor; Ubl conjugation pathway.
FT   CHAIN           1..254
FT                   /note="Cytokine-inducible SH2-containing protein"
FT                   /id="PRO_0000244527"
FT   DOMAIN          82..188
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   DOMAIN          205..253
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT   REGION          171..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   254 AA;  28397 MW;  FC5870784F43639B CRC64;
     MVLCVQGLCP LLAVEQIGQR PLWAQSLELP QQVMQPLSAG AFLEEAVEES PAQPEREPKV
     VDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV
     KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCAAD TRSDSPDLAT
     TPALPTPKED APGDPALPAT AVHLKLVQPF VRRSSTRSLQ HLCRLVINRL VVDVDCLPLP
     RRMADYLRQY PFQL