CISH_CHICK
ID CISH_CHICK Reviewed; 249 AA.
AC Q9PW70;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Cytokine-inducible SH2-containing protein;
DE Short=CIS;
DE AltName: Full=CIS-1;
DE AltName: Full=Suppressor of cytokine signaling;
DE Short=SOCS;
GN Name=CISH; Synonyms=CIS;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn;
RX PubMed=10918612; DOI=10.1038/sj.onc.1203691;
RA Fu S.-L., Waha A., Vogt P.K.;
RT "Identification and characterization of genes upregulated in cells
RT transformed by v-Jun.";
RL Oncogene 19:3537-3545(2000).
CC -!- FUNCTION: SOCS family proteins form part of a classical negative
CC feedback system that regulates cytokine signal transduction. CIS is
CC involved in the negative regulation of cytokines that signal through
CC the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin
CC 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its
CC tyrosine phosphorylation. May be a substrate-recognition component of a
CC SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein
CC ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins (By similarity).
CC {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin ligase
CC complexes. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF167297; AAD46657.1; -; mRNA.
DR RefSeq; NP_989957.1; NM_204626.1.
DR AlphaFoldDB; Q9PW70; -.
DR SMR; Q9PW70; -.
DR STRING; 9031.ENSGALP00000003536; -.
DR PaxDb; Q9PW70; -.
DR GeneID; 395335; -.
DR KEGG; gga:395335; -.
DR CTD; 1154; -.
DR VEuPathDB; HostDB:geneid_395335; -.
DR eggNOG; KOG4566; Eukaryota.
DR HOGENOM; CLU_079452_4_1_1; -.
DR InParanoid; Q9PW70; -.
DR OrthoDB; 1135696at2759; -.
DR PhylomeDB; Q9PW70; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9PW70; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR CDD; cd10718; SH2_CIS; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR028425; CIS.
DR InterPro; IPR035887; CIS_SH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155:SF9; PTHR10155:SF9; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation; Reference proteome; SH2 domain;
KW Signal transduction inhibitor; Ubl conjugation pathway.
FT CHAIN 1..249
FT /note="Cytokine-inducible SH2-containing protein"
FT /id="PRO_0000181234"
FT DOMAIN 84..165
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT DOMAIN 200..248
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT REGION 41..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 249 AA; 28118 MW; 994A08097B313B60 CRC64;
MILCVPGPHP LLAEEKIQRL SLRGIAEDLT EHIMQPLPVP AFPEEPAPTF AAPEPDGSAP
QTRDPEEDLL CIAKTFSYLR ESGWYWGSIT ASEAKQHLQK MPEGTFLVRD STHPSYLFTL
SVKTNRGPTN VRIEYADSKF RLDSNYLSKP RILAFPDVVS LIQHYVTSCT TESKSEAPYP
PPAPLPPVQK EVAVAAVHLK LLRPLGRRDS IPSLQHLCRL RINRCTTEVE RLPLPRRMGD
YLKQYPFQL
