ID   CISY1_RHITR             Reviewed;         429 AA.
AC   P51037;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Citrate synthase, chromosomal;
DE            EC=2.3.3.16;
GN   Name=ccsA;
OS   Rhizobium tropici.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=398;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CFN 299;
RX   PubMed=8526514; DOI=10.1128/aem.61.11.3992-3997.1995;
RA   Hernandez-Lucas I., Pardo M.A., Segovia L., Miranda J., Martinez-Romero E.;
RT   "Rhizobium tropici chromosomal citrate synthase gene.";
RL   Appl. Environ. Microbiol. 61:3992-3997(1995).
RN   [2]
RP   SEQUENCE REVISION.
RA   Rios J.M.;
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10117};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC       from oxaloacetate: step 1/2.
CC   -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}.
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DR   EMBL; L41815; AAB97876.1; -; Genomic_DNA.
DR   AlphaFoldDB; P51037; -.
DR   SMR; P51037; -.
DR   UniPathway; UPA00223; UER00717.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06114; EcCS_like; 1.
DR   Gene3D; 1.10.230.10; -; 1.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01798; cit_synth_I; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Transferase; Tricarboxylic acid cycle.
FT   CHAIN           1..429
FT                   /note="Citrate synthase, chromosomal"
FT                   /id="PRO_0000169954"
FT   ACT_SITE        306
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT   ACT_SITE        364
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
SQ   SEQUENCE   429 AA;  47976 MW;  EBED70CBFD6948EE CRC64;
     MTEQSAKLTW GEKTVDLPVK TGTIGPSVID IGALYKNTST FTYDPGFTST ASCESSITFI
     DGDEGVLLHR GYPIEQLAEH GDFLEVCYLL LYGELPTAAQ KKDFDYRVVH HTMVHEQMSR
     FFTGFRRDAH PMAVMCGCVG ALSAFYHDST DITDPHQRMV ASLRMIAKMP TLAAMAYKYH
     IGQPFVYPKN DLDYASNFLR MCFAVPCEEY VVNPVLARAM DRIFILHADH EQNASTSTVR
     LAGSSGANPF ACIAAGIACL WGPAHGGANE AALNMLTEIG TVDRIPEYIA RAKDKNDPFR
     LMGFGHRVYK NYDPRAKIMQ KTAHEVLGEL GIKDDPLLDI AIELERIALT DDYFIEKKLY
     PNVDFYSGIT LKALGFPTTM FTVLFALART VGWIAQWNEM IEDPDQRIGR PRHVYTGAPL
     REYVPVSKR