ACH92_ONCMY
ID ACH92_ONCMY Reviewed; 550 AA.
AC Q68RJ7;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Neuronal acetylcholine receptor subunit alpha-9-II;
DE AltName: Full=Nicotinic acetylcholine receptor subunit alpha-9-II;
DE Short=NACHR alpha-9-II;
DE Flags: Precursor;
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Saccule;
RX PubMed=15283971; DOI=10.1016/j.neuroscience.2004.05.037;
RA Drescher D.G., Ramakrishnan N.A., Drescher M.J., Chun W., Wang X.,
RA Myers S.F., Green G.E., Sadrazodi K., Karadaghy A.A., Poopat N.,
RA Karpenko A.N., Khan K.M., Hatfield J.S.;
RT "Cloning and characterization of alpha9 subunits of the nicotinic
RT acetylcholine receptor expressed by saccular hair cells of the rainbow
RT trout (Oncorhynchus mykiss).";
RL Neuroscience 127:737-752(2004).
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, liver, olfactory mucosa,
CC pituitary gland and hair cells of the saccule.
CC {ECO:0000269|PubMed:15283971}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. {ECO:0000305}.
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DR EMBL; AY611482; AAT45203.1; -; mRNA.
DR RefSeq; NP_001117991.1; NM_001124519.1.
DR AlphaFoldDB; Q68RJ7; -.
DR SMR; Q68RJ7; -.
DR Ensembl; ENSOMYT00000009003; ENSOMYP00000008106; ENSOMYG00000004143.
DR GeneID; 100136255; -.
DR KEGG; omy:100136255; -.
DR CTD; 55584; -.
DR GeneTree; ENSGT00940000156077; -.
DR OrthoDB; 845098at2759; -.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Signal; Synapse; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..550
FT /note="Neuronal acetylcholine receptor subunit alpha-9-II"
FT /id="PRO_0000000375"
FT TOPO_DOM 21..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..528
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 529..549
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 357..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 150..164
FT /evidence="ECO:0000250"
FT DISULFID 214..215
FT /note="Associated with receptor activation"
FT /evidence="ECO:0000250"
SQ SEQUENCE 550 AA; 61771 MW; 6352395FE46BB997 CRC64;
MRKMVPVVCF ATMLLQVAHS AQGRYAQQLL TDLMENYSNA LRPVEDTDKA LNVTLQITLS
QIKDMDERNQ VLIAYLWIRQ TWHDAYLRWN KEDYDGLEVI RIPSSLVWRP DLVLYNKADD
DFSGPLDTNV VLRYNGEITW DAPAITKSSC VVDVSYFPFD SQECNLTFGS WTYNGNQVDI
AMGMDSGDLS DFVENVEWEC HGMPATKNVI MYGCCSDPYP DITYTVLLQR RSSFYIFNLL
LPCFLISFLA PLGFYLPADS GEKVSLGVTV LLALTVFQLM VAESMPPSES VPLIGKYYIA
TMTMITASTA LTIFIMNIHF CGAEAKPVPH WAKVLIIDYM SKIFFVYEVG ENCATATSSS
SSSSSSSHFG QDDVHQPNFS SHRQANGKPG GNSGRENQYR HKNPRPQTPG PQRHPKPRHQ
HHITRDEKNH LSSSKYEGFE SNRNLPLGDC CKEAPPCCPE DEKTAVVAAA VASVTFGPCV
FCSHGSSLPG VDSKLVRNVE YIANCFREQR ATCAKGAEWK RVAKVMDRFF MWIFFIMVFL
MSILIIGKAP
