CISY_BARDO
ID CISY_BARDO Reviewed; 320 AA.
AC Q59198;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Citrate synthase;
DE EC=2.3.3.16;
DE Flags: Fragment;
GN Name=gltA;
OS Bartonella doshiae.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bartonellaceae; Bartonella.
OX NCBI_TaxID=33044;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R18;
RX PubMed=8863415; DOI=10.1099/00207713-46-4-891;
RA Birtles R.J., Raoult D.;
RT "Comparison of partial citrate synthase gene (gltA) sequences for
RT phylogenetic analysis of Bartonella species.";
RL Int. J. Syst. Bacteriol. 46:891-897(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16; Evidence={ECO:0000255|PROSITE-
CC ProRule:PRU10117};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2.
CC -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells capable of
CC oxidative metabolism.
CC -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}.
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DR EMBL; Z70017; CAA93839.1; -; Genomic_DNA.
DR AlphaFoldDB; Q59198; -.
DR SMR; Q59198; -.
DR STRING; 1094553.MCS_00222; -.
DR UniPathway; UPA00223; UER00717.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.230.10; -; 1.
DR Gene3D; 1.10.580.10; -; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR010953; Citrate_synthase_typ-I.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; SSF48256; 1.
DR TIGRFAMs; TIGR01798; cit_synth_I; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Transferase; Tricarboxylic acid cycle.
FT CHAIN <1..>320
FT /note="Citrate synthase"
FT /id="PRO_0000169932"
FT ACT_SITE 249
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT ACT_SITE 307
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT NON_TER 1
FT NON_TER 320
SQ SEQUENCE 320 AA; 36285 MW; 22F7BA8B2452297C CRC64;
TYIDGDKGIL LYRGYPIEQL AEKGDFLESC YLLLYGELPT QQEKNDFDRR IMQHTMVHEQ
FSRFFQGFRR DSHPMAVMVA CLGAMSAFYH DSIDITDPQQ RMIASIRLIS KVPTLAAMAY
KYSIGQAFVY PHNSLSYAAN FLRMCFAVPC EEYQVNPVLT RAMDRIFILH ADHEQNASTS
TVRLAGSSGA NPFACIAAGV ACLWGPAHGG ANEACLKMLK EIGSVKKIPE FIARAKDKND
PFRLMGFGHR VYKNYDPRAK IMQKTCHEVL KELNRQDDPL LDIAIELEHI ALNDEYFIEK
KLYPNVDFYS GITLKALGFP