ACHA2_CHICK
ID ACHA2_CHICK Reviewed; 528 AA.
AC P09480;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Neuronal acetylcholine receptor subunit alpha-2;
DE Flags: Precursor;
GN Name=CHRNA2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=White leghorn; TISSUE=Brain;
RX PubMed=3267226; DOI=10.1002/j.1460-2075.1988.tb02852.x;
RA Nef P., Oneyser C., Alliod C., Couturier S., Ballivet M.;
RT "Genes expressed in the brain define three distinct neuronal nicotinic
RT acetylcholine receptors.";
RL EMBO J. 7:595-601(1988).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC -!- SUBUNIT: Neuronal AChR seems to be composed of two different type of
CC subunits: alpha and non-alpha (also called beta). A functional receptor
CC seems to consist of two alpha-chains and three non-alpha chains.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; X07339; CAB59645.1; -; Genomic_DNA.
DR EMBL; X07340; CAB59645.1; JOINED; Genomic_DNA.
DR EMBL; X07341; CAB59645.1; JOINED; Genomic_DNA.
DR EMBL; X07342; CAB59645.1; JOINED; Genomic_DNA.
DR EMBL; X07343; CAB59645.1; JOINED; Genomic_DNA.
DR EMBL; X07344; CAB59645.1; JOINED; Genomic_DNA.
DR EMBL; AJ250360; CAB59625.1; -; mRNA.
DR PIR; S00377; ACCH2N.
DR RefSeq; NP_990146.1; NM_204815.2.
DR AlphaFoldDB; P09480; -.
DR SMR; P09480; -.
DR ComplexPortal; CPX-179; Neuronal nicotinic acetylcholine receptor complex, alpha2-beta2.
DR ComplexPortal; CPX-184; Neuronal nicotinic acetylcholine receptor complex, alpha2-beta4.
DR IntAct; P09480; 2.
DR STRING; 9031.ENSGALP00000026687; -.
DR GeneID; 395607; -.
DR KEGG; gga:395607; -.
DR CTD; 1135; -.
DR VEuPathDB; HostDB:geneid_395607; -.
DR eggNOG; KOG3645; Eukaryota.
DR InParanoid; P09480; -.
DR OrthoDB; 381858at2759; -.
DR PhylomeDB; P09480; -.
DR PRO; PR:P09480; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IC:ComplexPortal.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..23
FT CHAIN 24..528
FT /note="Neuronal acetylcholine receptor subunit alpha-2"
FT /id="PRO_0000000344"
FT TOPO_DOM 24..239
FT /note="Extracellular"
FT TRANSMEM 240..264
FT /note="Helical"
FT TRANSMEM 272..290
FT /note="Helical"
FT TRANSMEM 306..327
FT /note="Helical"
FT TOPO_DOM 328..501
FT /note="Cytoplasmic"
FT TRANSMEM 502..520
FT /note="Helical"
FT REGION 390..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..410
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 158..172
FT /evidence="ECO:0000250"
FT DISULFID 222..223
FT /note="Associated with receptor activation"
FT /evidence="ECO:0000250"
SQ SEQUENCE 528 AA; 60675 MW; E76C6360AF876364 CRC64;
MGWPCRSIIP LLVWCFVTLQ AATREQKQPH GFAEDRLFKH LFTGYNRWSR PVPNTSDVVI
VKFGLSIAQL IDVDEKNQMM TTNVWLKQEW SDYKLRWNPE DFDNVTSIRV PSEMIWIPDI
VLYNNADGEF AVTHMTKAHL FSNGKVKWVP PAIYKSSCSI DVTYFPFDQQ NCKMKFGSWT
YDKAKIDLEN MEHHVDLKDY WESGEWAIIN AIGRYNSKKY DCCTEIYPDI TFYFVIRRLP
LFYTINLIIP CLLISCLTVL VFYLPSDCGE KITLCISVLL SLTVFLLLIT EIIPSTSLVI
PLIGEYLLFT MIFVTLSIII TVFVLNVHHR SPSTHTMPHW VRSFFLGFIP RWLFMKRPPL
LLPAEGTTGQ YDPPGTRLST SRCWLETDVD DKWEEEEEEE EEEEEEEEEE KAYPSRVPSG
GSQGTQCHYS CERQAGKASG GPAPQVPLKG EEVGSDQGLT LSPSILRALE GVQYIADHLR
AEDADFSVKE DWKYVAMVID RIFLWMFIIV CLLGTVGLFL PPYLAGMI
