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CISY_HELPJ
ID   CISY_HELPJ              Reviewed;         426 AA.
AC   Q9ZN37;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Citrate synthase;
DE            EC=2.3.3.16;
GN   Name=gltA; OrderedLocusNames=jhp_0022;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10117};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC       from oxaloacetate: step 1/2.
CC   -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells capable of
CC       oxidative metabolism.
CC   -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}.
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DR   EMBL; AE001439; AAD05606.1; -; Genomic_DNA.
DR   PIR; D71982; D71982.
DR   RefSeq; WP_000117349.1; NC_000921.1.
DR   AlphaFoldDB; Q9ZN37; -.
DR   SMR; Q9ZN37; -.
DR   IntAct; Q9ZN37; 2.
DR   STRING; 85963.jhp_0022; -.
DR   EnsemblBacteria; AAD05606; AAD05606; jhp_0022.
DR   KEGG; hpj:jhp_0022; -.
DR   eggNOG; COG0372; Bacteria.
DR   OMA; TVGWCAQ; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06114; EcCS_like; 1.
DR   Gene3D; 1.10.230.10; -; 1.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Transferase; Tricarboxylic acid cycle.
FT   CHAIN           1..426
FT                   /note="Citrate synthase"
FT                   /id="PRO_0000169947"
FT   ACT_SITE        314
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT   ACT_SITE        372
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
SQ   SEQUENCE   426 AA;  48262 MW;  373FEE23B1C6239A CRC64;
     MSVTLINNEN NARYEFETIE CTRGPKAVDF SKLFETTGFF SYDPGYSSTA GCQSKISYIN
     GKKGELYYRG HRIEDLVAKY KYVDVCRLLL TGELPKNQDE SLEFELELRH RSFVHESLLN
     MFSAFPSNAH PMAKLSSGVS ILSTLYSTHQ NMHTEEDYQT MARRIVAKIP TLAAICYRNE
     VGAPIIYPDI ARSYVENILF MLRGYPYSRL KHTTQGEVGI TPLEVEAFDK ILTLHADHGQ
     NASSTTVRNV ASTGVHPYAA ISAGISALWG HLHGGANEKV LLQLEEIGDV KNVDKYIARV
     KDKNDNFKLM GFGHRVYKSY DPRAKILKGL KDELHQKGVK MDERLSEIAA KVEEIALKDE
     YFIERNLYPN VDFYSGTILR ALKIPVRFFT PVFVIGRTVG WCAQLLEHVK SPQARITRPR
     QVYVGD
 
 
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