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CISY_RHIME
ID   CISY_RHIME              Reviewed;         429 AA.
AC   O33915;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Citrate synthase;
DE            EC=2.3.3.16;
GN   Name=gltA; OrderedLocusNames=R01509; ORFNames=SMc02087;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=104A14;
RA   Mortimer M.W., McDermott T.R., Kahn M.L.;
RT   "Isolation and characterization of a gene coding for citrate synthase from
RT   Rhizobium meliloti.";
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10117};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC       from oxaloacetate: step 1/2.
CC   -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}.
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DR   EMBL; U75365; AAB82405.1; -; Genomic_DNA.
DR   EMBL; AL591688; CAC46088.1; -; Genomic_DNA.
DR   RefSeq; NP_385615.1; NC_003047.1.
DR   RefSeq; WP_010969265.1; NC_003047.1.
DR   AlphaFoldDB; O33915; -.
DR   SMR; O33915; -.
DR   STRING; 266834.SMc02087; -.
DR   PRIDE; O33915; -.
DR   EnsemblBacteria; CAC46088; CAC46088; SMc02087.
DR   GeneID; 61602972; -.
DR   KEGG; sme:SMc02087; -.
DR   PATRIC; fig|266834.11.peg.2930; -.
DR   eggNOG; COG0372; Bacteria.
DR   HOGENOM; CLU_025068_0_0_5; -.
DR   OMA; TVGWCAQ; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06114; EcCS_like; 1.
DR   Gene3D; 1.10.230.10; -; 1.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01798; cit_synth_I; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Tricarboxylic acid cycle.
FT   CHAIN           1..429
FT                   /note="Citrate synthase"
FT                   /id="PRO_0000169953"
FT   ACT_SITE        306
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT   ACT_SITE        364
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT   CONFLICT        209
FT                   /note="E -> D (in Ref. 1; AAB82405)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        229
FT                   /note="D -> N (in Ref. 1; AAB82405)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        282
FT                   /note="V -> A (in Ref. 1; AAB82405)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        290
FT                   /note="T -> A (in Ref. 1; AAB82405)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        355
FT                   /note="I -> V (in Ref. 1; AAB82405)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        427
FT                   /note="S -> T (in Ref. 1; AAB82405)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   429 AA;  48002 MW;  F28D1C61427974F8 CRC64;
     MSEKSATVTF GGKSADLPVR SGSIGPDVVD IGSLYKQTTM FTYDPGFTST ASCESKITYI
     DGDEGVLLHR GFPIEQLAEH GDFLEVCYLL LYGELPTKAQ KADFDYRVTH HTMVHEQMSR
     FFTGFRRDAH PMAVMCGCVG ALSAFYHDST DITDPHQRMV ASLRMIAKMP TIAAMAYKYH
     IGQPFVYPKN DLDYASNFLR MCFAVPCEEY VVNPVLARAM DRIFILHADH EQNASTSTVR
     LAGSSGANPF ACIAAGIACL WGPAHGGANE AALNMLAEIG TVDRIPEYIT KAKDKNDPFR
     LMGFGHRVYK NYDPRAKIMQ KTTHEVLAEL GHKDDPLLEV AMELERIALT DEYFIEKKLY
     PNIDFYSGIT LKALGFPTTM FTVLFALART VGWIAQWNEM IEDPEQRIGR PRQLYVGAPL
     RDYVPISKR
 
 
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