CISY_RICC1
ID CISY_RICC1 Reviewed; 411 AA.
AC Q59136;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Citrate synthase;
DE EC=2.3.3.16;
DE Flags: Fragment;
GN Name=gltA;
OS Rickettsia conorii subsp. caspia (strain A-167) (Astrakhan rickettsia).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=140892;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=A-167;
RX PubMed=9103608; DOI=10.1099/00207713-47-2-252;
RA Roux V., Rydkina E., Eremeeva M., Raoult D.;
RT "Citrate synthase gene comparison, a new tool for phylogenetic analysis,
RT and its application for the rickettsiae.";
RL Int. J. Syst. Bacteriol. 47:252-261(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16; Evidence={ECO:0000255|PROSITE-
CC ProRule:PRU10117};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2.
CC -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells capable of
CC oxidative metabolism.
CC -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}.
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DR EMBL; U59728; AAB02951.1; -; Genomic_DNA.
DR AlphaFoldDB; Q59136; -.
DR SMR; Q59136; -.
DR PRIDE; Q59136; -.
DR UniPathway; UPA00223; UER00717.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06114; EcCS_like; 1.
DR Gene3D; 1.10.230.10; -; 1.
DR Gene3D; 1.10.580.10; -; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR010953; Citrate_synthase_typ-I.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; SSF48256; 1.
DR TIGRFAMs; TIGR01798; cit_synth_I; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Transferase; Tricarboxylic acid cycle.
FT CHAIN <1..>411
FT /note="Citrate synthase"
FT /id="PRO_0000169926"
FT ACT_SITE 304
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT ACT_SITE 363
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT NON_TER 1
FT NON_TER 411
SQ SEQUENCE 411 AA; 46160 MW; 7A5692879D305B99 CRC64;
DSEFAELKIR GKIFKLPILK ASIGEDVIDI SRVSAEADCF TYDPGFMSTA SCQSTITYID
GDKGILRHRG YDIKDLAEKS DFLEVAYLLI YGELPSGEQY NNFTKQVAHH SLVNERLHYL
FQTFCSSSHP MAIMLAAVGS LSAFYPDLLN FKEADYELTA IRMIAKIPTI AAMSYKYSIG
QPFIYPDNPL DFTENFLHMM FATPCTKYTV NPIIKNALNK IFILHADHEQ NASTSTVRIA
GSSGANPFAC ISTGIASLWG PAHGGANEAV INMLKEIGSS EYIPKYIAKA KDKNDPFRLM
GFGHRVYKNY DPRAAVLKET CKEVLKALGQ LDNNPLLQIA IELEAIALKD EYFIERKLYP
NVDFYSGIIY KAMGIPSQMF TVLFAIARTV GWMAQWKEMH EDPEQKISRP R