ID   CISY_STRMU              Reviewed;         372 AA.
AC   Q59939;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Citrate synthase;
DE            EC=2.3.3.16;
GN   Name=citZ; OrderedLocusNames=SMU_671;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=JH1005;
RX   PubMed=9006016; DOI=10.1128/jb.179.3.650-655.1997;
RA   Cvitkovitch D.G., Gutierrez J.A., Bleiweis A.S.;
RT   "Role of the citrate pathway in glutamate biosynthesis by Streptococcus
RT   mutans.";
RL   J. Bacteriol. 179:650-655(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10117};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC       from oxaloacetate: step 1/2.
CC   -!- MISCELLANEOUS: Citrate synthase is found in nearly all cells capable of
CC       oxidative metabolism.
CC   -!- SIMILARITY: Belongs to the citrate synthase family. {ECO:0000305}.
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DR   EMBL; U62799; AAC44825.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN58405.1; -; Genomic_DNA.
DR   RefSeq; NP_721099.1; NC_004350.2.
DR   RefSeq; WP_002261870.1; NC_004350.2.
DR   AlphaFoldDB; Q59939; -.
DR   SMR; Q59939; -.
DR   STRING; 210007.SMU_671; -.
DR   PRIDE; Q59939; -.
DR   EnsemblBacteria; AAN58405; AAN58405; SMU_671.
DR   KEGG; smu:SMU_671; -.
DR   PATRIC; fig|210007.7.peg.596; -.
DR   eggNOG; COG0372; Bacteria.
DR   HOGENOM; CLU_025068_2_1_9; -.
DR   OMA; TVGWCAQ; -.
DR   PhylomeDB; Q59939; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.230.10; -; 1.
DR   Gene3D; 1.10.580.10; -; 1.
DR   InterPro; IPR011278; 2-MeCitrate/Citrate_synth_II.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   PANTHER; PTHR11739; PTHR11739; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; SSF48256; 1.
DR   TIGRFAMs; TIGR01800; cit_synth_II; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Transferase; Tricarboxylic acid cycle.
FT   CHAIN           1..372
FT                   /note="Citrate synthase"
FT                   /id="PRO_0000169973"
FT   ACT_SITE        258
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT   ACT_SITE        309
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10117"
FT   CONFLICT        40
FT                   /note="A -> T (in Ref. 1; AAC44825)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   372 AA;  42711 MW;  AC0EBA6DB6B847D3 CRC64;
     MAETNGLKDM IACDTRISAI KDNKLSYAGY DIADLMDNKA RFEEVIYLLW NLHLPTAIEL
     KQFEEKLRKN YAISDAIEQC ILIQSRQHLH PMSVLRSTVS LLGVYNLKAE ERSVEATYDQ
     SIQLMAKIPT IIATFARLRQ GLSPIAPRKD LGFAANFLYM LNGRLPSELE ILAMNRALVL
     HAEHELNAST FAARVCASTL SDIYSCVTTA IGTLKGPLHG GANERVFDML REIREYGDVD
     SYLQEKLNSK EKIMGFGHRV YQTQDPREKY LREMARELTK GTEHDIWYQL SKKVEICMKQ
     KKNLIPNVDF YSATVYHVLG IDSSIFTLIF AMSRVSGWIA HIQEQQKNNK LIRPRSHYTG
     MRKLRYIPIE RR