ACHA3_CHICK
ID ACHA3_CHICK Reviewed; 496 AA.
AC P09481;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Neuronal acetylcholine receptor subunit alpha-3;
DE Flags: Precursor;
GN Name=CHRNA3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1698777; DOI=10.1016/s0021-9258(18)38201-2;
RA Couturier S., Erkman L., Valera S., Rungger D., Bertrand S., Boulter J.,
RA Ballivet M., Bertrand D.;
RT "Alpha 5, alpha 3, and non-alpha 3. Three clustered avian genes encoding
RT neuronal nicotinic acetylcholine receptor-related subunits.";
RL J. Biol. Chem. 265:17560-17567(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-496.
RC STRAIN=White leghorn; TISSUE=Brain;
RX PubMed=3267226; DOI=10.1002/j.1460-2075.1988.tb02852.x;
RA Nef P., Oneyser C., Alliod C., Couturier S., Ballivet M.;
RT "Genes expressed in the brain define three distinct neuronal nicotinic
RT acetylcholine receptors.";
RL EMBO J. 7:595-601(1988).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC -!- SUBUNIT: Neuronal AChR seems to be composed of two different type of
CC subunits: alpha and non-alpha (also called beta). A functional receptor
CC seems to consist of two alpha-chains and three non-alpha chains.
CC -!- INTERACTION:
CC P09481; P26153: CHRNB4; NbExp=3; IntAct=EBI-10686191, EBI-10686176;
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- DEVELOPMENTAL STAGE: High levels in the developing ciliary and superior
CC cervical ganglia.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; M37336; AAA48559.1; -; mRNA.
DR EMBL; X07345; CAA30284.1; -; Genomic_DNA.
DR EMBL; X07346; CAA30284.1; JOINED; Genomic_DNA.
DR EMBL; X07347; CAA30284.1; JOINED; Genomic_DNA.
DR PIR; S00378; ACCH3N.
DR RefSeq; NP_989747.1; NM_204416.1.
DR AlphaFoldDB; P09481; -.
DR SMR; P09481; -.
DR ComplexPortal; CPX-192; Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2.
DR ComplexPortal; CPX-193; Neuronal nicotinic acetylcholine receptor complex, alpha3-beta2.
DR ComplexPortal; CPX-201; Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3.
DR ComplexPortal; CPX-206; Neuronal nicotinic acetylcholine receptor complex, alpha3-beta4.
DR ComplexPortal; CPX-207; Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4.
DR ComplexPortal; CPX-214; Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4.
DR IntAct; P09481; 3.
DR STRING; 9031.ENSGALP00000004750; -.
DR PaxDb; P09481; -.
DR Ensembl; ENSGALT00000004759; ENSGALP00000004750; ENSGALG00000003014.
DR GeneID; 386578; -.
DR KEGG; gga:386578; -.
DR CTD; 1136; -.
DR VEuPathDB; HostDB:geneid_386578; -.
DR eggNOG; KOG3645; Eukaryota.
DR GeneTree; ENSGT00940000158487; -.
DR InParanoid; P09481; -.
DR OMA; AEHRLYA; -.
DR OrthoDB; 381858at2759; -.
DR PhylomeDB; P09481; -.
DR Reactome; R-GGA-629587; Highly sodium permeable postsynaptic acetylcholine nicotinic receptors.
DR Reactome; R-GGA-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
DR PRO; PR:P09481; -.
DR Proteomes; UP000000539; Chromosome 10.
DR Bgee; ENSGALG00000003014; Expressed in spermatocyte and 3 other tissues.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IPI:ComplexPortal.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0015464; F:acetylcholine receptor activity; IEA:Ensembl.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0035095; P:behavioral response to nicotine; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051899; P:membrane depolarization; IC:ComplexPortal.
DR GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0060084; P:synaptic transmission involved in micturition; IEA:Ensembl.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..22
FT CHAIN 23..496
FT /note="Neuronal acetylcholine receptor subunit alpha-3"
FT /id="PRO_0000000349"
FT TOPO_DOM 23..231
FT /note="Extracellular"
FT TRANSMEM 232..256
FT /note="Helical"
FT TRANSMEM 264..282
FT /note="Helical"
FT TRANSMEM 298..319
FT /note="Helical"
FT TOPO_DOM 320..468
FT /note="Cytoplasmic"
FT TRANSMEM 469..488
FT /note="Helical"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 150..164
FT /evidence="ECO:0000250"
FT DISULFID 214..215
FT /note="Associated with receptor activation"
FT /evidence="ECO:0000250"
SQ SEQUENCE 496 AA; 57028 MW; FD25BC02A9B601FF CRC64;
MQSIHALLLT AAVCILFQGC GGSEPEHRLY AALFKNYNQF VRPVKNASDP VIIQFEVSMS
QLVKVDEVNQ IMETNLWLKH IWNDYKLRWN PVDYGGAEFI RVPSGQIWKP DIVLYNNAVG
DFQVDDKTKA LLKYTGDVTW IPPAIFKSSC KIDVTYFPFD YQNCTMKFGS WSYDKAKIDL
VLIGSTMNLK DYWESGEWAI IKAPGYKHDI KYNCCEEIYT DITYSLYIRR LPLFYTINMI
IPCLLISFLT VLVFYLPSDC GEKVTLCISV LLSLTVFLLV ITETIPSTSL VIPLIGEYLL
FTMIFVTLSI VITVFVLNVH YRTPKTHTMP VWVRTIFLNL LPRIMFMTRP TSDEENNQKP
KPFYTSEFSN LNCFNSSEIK CCKDGFVCQD MACSCCQYQR MKFSDFSGNL TRSSSSESVD
PLFSFSVLSP EMRDAIESVK YIAENMKMQN EAKEIQDDWK YVAMVIDRIF LWVFILVCIL
GTAGLFLQPL MTGDDM
