ACHA5_BOVIN
ID ACHA5_BOVIN Reviewed; 475 AA.
AC Q8SPU7;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Neuronal acetylcholine receptor subunit alpha-5;
DE Flags: Precursor;
GN Name=CHRNA5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9003033; DOI=10.1046/j.1471-4159.1997.68020488.x;
RA Campos-Caro A., Smillie F.I., Dominguez del Toro E., Rovira J.C.,
RA Vicente-Agullo F., Chapuli J., Juiz J.M., Sala S., Sala F., Ballesta J.J.,
RA Criado M.;
RT "Neuronal nicotinic acetylcholine receptors on bovine chromaffin cells:
RT cloning, expression, and genomic organization of receptor subunits.";
RL J. Neurochem. 68:488-497(1997).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC {ECO:0000250}.
CC -!- SUBUNIT: Neuronal AChR seems to be composed of two different types of
CC subunits: alpha and non-alpha (beta). Interacts with LYPD6.
CC {ECO:0000250|UniProtKB:P30532}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; AF487464; AAL88711.1; -; mRNA.
DR RefSeq; NP_776939.1; NM_174514.2.
DR AlphaFoldDB; Q8SPU7; -.
DR SMR; Q8SPU7; -.
DR PaxDb; Q8SPU7; -.
DR PRIDE; Q8SPU7; -.
DR Ensembl; ENSBTAT00000018151; ENSBTAP00000018151; ENSBTAG00000013657.
DR GeneID; 282177; -.
DR KEGG; bta:282177; -.
DR CTD; 1138; -.
DR VEuPathDB; HostDB:ENSBTAG00000013657; -.
DR VGNC; VGNC:27327; CHRNA5.
DR eggNOG; KOG3645; Eukaryota.
DR GeneTree; ENSGT00940000159270; -.
DR HOGENOM; CLU_018074_1_2_1; -.
DR InParanoid; Q8SPU7; -.
DR OMA; KWANIII; -.
DR OrthoDB; 381858at2759; -.
DR Reactome; R-BTA-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000013657; Expressed in prostate gland and 71 other tissues.
DR ExpressionAtlas; Q8SPU7; baseline.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IEA:Ensembl.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0098691; C:dopaminergic synapse; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0015464; F:acetylcholine receptor activity; IEA:Ensembl.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0035095; P:behavioral response to nicotine; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
DR GO; GO:0035094; P:response to nicotine; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 2.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..475
FT /note="Neuronal acetylcholine receptor subunit alpha-5"
FT /id="PRO_0000244646"
FT TOPO_DOM 30..261
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..437
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 459..475
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 236
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 177..191
FT /evidence="ECO:0000250"
FT DISULFID 241..242
FT /note="Associated with receptor activation"
FT /evidence="ECO:0000250"
SQ SEQUENCE 475 AA; 54260 MW; 24658023DF0E3D1A CRC64;
MAAPGWGRWV LGLGPLLLQV FLPFQLVAGR WGPEGAGGGV RRGLAEPSVV AKHEDSLFKD
LFQDYERWVR PVEHLNDRIK IKFGLAISQL VDVDEKNQLM TTNVWLKQEW IDVKLRWNPD
DYGGIKLIRV PSDSLWTPDI VLFDNADGRF EGASTKTVVR YDGTVTWTPP ANYKSSCTID
VTFFPFDLQN CSMKFGSWTY DGSQVDIILE DQDVDKRDFF DNGEWEIVSA TGSKGNRTDS
CCWYPYITYS FVIKRLPLFY TLFLIIPCIG LSFLTVLVFY LPSNEGEKIC LCTSVLVSLT
VFLLVIEEII PSSSKVIPLI GEYLVFTMIF VTLSIMVTVF AINIHHRSSS THDAMAPWVR
KIFLHKLPKL LCMRSHVDRY FSQKEEARSS RGPRSSRNAL EAALDSVRYI TRHVMKETDV
REVVEDWKFI AQVLDRMFLW TFLLVSVVGS LGLFVPVIYK WANIIVPIHI GNENK
