ACHA5_CHICK
ID ACHA5_CHICK Reviewed; 454 AA.
AC P26152;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Neuronal acetylcholine receptor subunit alpha-5;
DE Flags: Precursor;
GN Name=CHRNA5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Brain;
RX PubMed=1698777; DOI=10.1016/s0021-9258(18)38201-2;
RA Couturier S., Erkman L., Valera S., Rungger D., Bertrand S., Boulter J.,
RA Ballivet M., Bertrand D.;
RT "Alpha 5, alpha 3, and non-alpha 3. Three clustered avian genes encoding
RT neuronal nicotinic acetylcholine receptor-related subunits.";
RL J. Biol. Chem. 265:17560-17567(1990).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC -!- SUBUNIT: Neuronal AChR seems to be composed of two different type of
CC subunits: alpha and non-alpha (also called beta). A functional receptor
CC seems to consist of two alpha-chains and three non-alpha chains.
CC -!- INTERACTION:
CC P26152; P09484: CHRNB2; NbExp=8; IntAct=EBI-10686157, EBI-10686072;
CC P26152; P26153: CHRNB4; NbExp=4; IntAct=EBI-10686157, EBI-10686176;
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; J05642; AAA48560.1; -; mRNA.
DR PIR; B39218; B39218.
DR RefSeq; NP_989746.1; NM_204415.1.
DR AlphaFoldDB; P26152; -.
DR SMR; P26152; -.
DR ComplexPortal; CPX-192; Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2.
DR ComplexPortal; CPX-207; Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4.
DR ComplexPortal; CPX-217; Neuronal nicotinic acetylcholine receptor complex, alpha4-alpha5-beta2.
DR IntAct; P26152; 4.
DR STRING; 9031.ENSGALP00000004767; -.
DR PaxDb; P26152; -.
DR GeneID; 386577; -.
DR KEGG; gga:386577; -.
DR CTD; 1138; -.
DR VEuPathDB; HostDB:geneid_386577; -.
DR eggNOG; KOG3645; Eukaryota.
DR InParanoid; P26152; -.
DR OrthoDB; 381858at2759; -.
DR PhylomeDB; P26152; -.
DR PRO; PR:P26152; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IPI:ComplexPortal.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0035094; P:response to nicotine; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 2.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..454
FT /note="Neuronal acetylcholine receptor subunit alpha-5"
FT /id="PRO_0000000359"
FT TOPO_DOM 30..240
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..416
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 438..454
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 156..170
FT /evidence="ECO:0000250"
FT DISULFID 220..221
FT /note="Associated with receptor activation"
FT /evidence="ECO:0000250"
SQ SEQUENCE 454 AA; 51957 MW; A33D79ED1F799776 CRC64;
MPLRARSRKP GAGPAARAPQ AGVSEPSFVA KSEDRLFKHL FEDYQRWVRP VEHLNDTIKI
KFGLAISQLV DVDEKNQLMT TNVWLKQEWI HVKLRWNPED YAGITSIRVP SDSIWIPDIV
LYDNADGRFE GTSTKTVVKY DGTIAWTPPV NYKSSCTIDV TFFPFDLQNC SMKFGSWTYD
GSQVDIILED YEVDKRDFFD NGEWEIVTAT GSKGNRTDGC CWYPFVTYSF IIRRLPLFYT
LFLIIPCIGL SFLTVLVFYL PSNEAEKISL CTSVLVSLTV FLLVIEEIIP SSSKVIPLIG
EYLVFTMIFV TLSIVITVFA INIHHRSSST HNAMAPWVRK IFLHKLPKLL CMRSHVDRYF
AQKEEKGNMS GSESSRNTLE AALDSIRYIT RHVMKENEVR EVVEDWKFIA QVLDRMFLWA
FLLVSIIGSL VLFIPVIHKW ASIIVPVHIG STNT
