CITE2_BOVIN
ID CITE2_BOVIN Reviewed; 273 AA.
AC Q0VCT9;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Cbp/p300-interacting transactivator 2;
GN Name=CITED2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional coactivator of the p300/CBP-mediated
CC transcription complex. Acts as a bridge, linking TFAP2 transcription
CC factors and the p300/CBP transcriptional coactivator complex in order
CC to stimulate TFAP2-mediated transcriptional activation. Positively
CC regulates TGF-beta signaling through its association with the
CC SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates
CC the peroxisome proliferator-activated receptors PPARA transcriptional
CC activity. Enhances estrogen-dependent transactivation mediated by
CC estrogen receptors. Acts also as a transcriptional corepressor;
CC interferes with the binding of the transcription factors HIF1A or STAT2
CC and the p300/CBP transcriptional coactivator complex. Participates in
CC sex determination and early gonad development by stimulating
CC transcription activation of SRY. Plays a role in controlling left-right
CC patterning during embryogenesis; potentiates transcriptional activation
CC of NODAL-mediated gene transcription in the left lateral plate mesoderm
CC (LPM). Plays an essential role in differentiation of the adrenal cortex
CC from the adrenogonadal primordium (AGP); stimulates WT1-mediated
CC transcription activation thereby up-regulating the nuclear hormone
CC receptor NR5A1 promoter activity. Associates with chromatin to the
CC PITX2 P1 promoter region.
CC -!- SUBUNIT: Interacts (via C-terminus) with SMAD2. Interacts (via C-
CC terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM
CC domains). Interacts with WT1 (By similarity). Interacts (via C-
CC terminus) with EP300 (via CH1 domain); the interaction is stimulated in
CC response to hypoxia. Interacts with PPARA. Interacts (via C-terminus)
CC with TFAP2A, TFAP2B and TFAP2C. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with
CC EP300 in dot-like structures. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CITED family. {ECO:0000305}.
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DR EMBL; BC120010; AAI20011.1; -; mRNA.
DR RefSeq; NP_001069287.1; NM_001075819.1.
DR AlphaFoldDB; Q0VCT9; -.
DR SMR; Q0VCT9; -.
DR STRING; 9913.ENSBTAP00000014907; -.
DR PaxDb; Q0VCT9; -.
DR PRIDE; Q0VCT9; -.
DR Ensembl; ENSBTAT00000014907; ENSBTAP00000014907; ENSBTAG00000011224.
DR GeneID; 521378; -.
DR KEGG; bta:521378; -.
DR CTD; 10370; -.
DR VEuPathDB; HostDB:ENSBTAG00000011224; -.
DR VGNC; VGNC:27377; CITED2.
DR eggNOG; ENOG502QSRC; Eukaryota.
DR GeneTree; ENSGT00530000063624; -.
DR HOGENOM; CLU_090678_1_0_1; -.
DR InParanoid; Q0VCT9; -.
DR OMA; HAMGPGN; -.
DR OrthoDB; 1378769at2759; -.
DR TreeFam; TF331915; -.
DR Reactome; R-BTA-8866907; Activation of the TFAP2 (AP-2) family of transcription factors.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000011224; Expressed in myometrium and 108 other tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0035035; F:histone acetyltransferase binding; IEA:Ensembl.
DR GO; GO:0050693; F:LBD domain binding; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0046332; F:SMAD binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR GO; GO:0035802; P:adrenal cortex formation; ISS:UniProtKB.
DR GO; GO:0060349; P:bone morphogenesis; IEA:Ensembl.
DR GO; GO:0061308; P:cardiac neural crest cell development involved in heart development; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0021602; P:cranial nerve morphogenesis; IEA:Ensembl.
DR GO; GO:0046697; P:decidualization; IEA:Ensembl.
DR GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IEA:Ensembl.
DR GO; GO:0060971; P:embryonic heart tube left/right pattern formation; IEA:Ensembl.
DR GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
DR GO; GO:0060136; P:embryonic process involved in female pregnancy; IEA:Ensembl.
DR GO; GO:0003197; P:endocardial cushion development; IEA:Ensembl.
DR GO; GO:0048821; P:erythrocyte development; IEA:Ensembl.
DR GO; GO:0030851; P:granulocyte differentiation; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0070986; P:left/right axis specification; IEA:Ensembl.
DR GO; GO:0060972; P:left/right pattern formation; IBA:GO_Central.
DR GO; GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0061428; P:negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:1900164; P:nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; IEA:Ensembl.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0007422; P:peripheral nervous system development; IEA:Ensembl.
DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:2000020; P:positive regulation of male gonad development; ISS:UniProtKB.
DR GO; GO:0035360; P:positive regulation of peroxisome proliferator activated receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0061156; P:pulmonary artery morphogenesis; IEA:Ensembl.
DR GO; GO:0003156; P:regulation of animal organ formation; ISS:UniProtKB.
DR GO; GO:0043627; P:response to estrogen; ISS:UniProtKB.
DR GO; GO:0034405; P:response to fluid shear stress; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR GO; GO:0007530; P:sex determination; ISS:UniProtKB.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001829; P:trophectodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR InterPro; IPR007576; CITED.
DR PANTHER; PTHR17045; PTHR17045; 1.
DR Pfam; PF04487; CITED; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..273
FT /note="Cbp/p300-interacting transactivator 2"
FT /id="PRO_0000285515"
FT REGION 138..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 144..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 273 AA; 28710 MW; 8A5E9E10E572DD31 CRC64;
MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA
SNMNASSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG PPVASQGGSL PASMQLQKLN
NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSA
GTSGGGAGSS NSGGGSGGGS SSNMPASVAH VPAAVLPPNV IDTDFIDEEV LMSLVIEMGL
DRIKELPELW LGQNEFDFMT DFVCKQQPSR VSC