ID   CITE2_SAGLB             Reviewed;         273 AA.
AC   A1YFU7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   02-JUN-2021, entry version 38.
DE   RecName: Full=Cbp/p300-interacting transactivator 2;
GN   Name=CITED2;
OS   Saguinus labiatus (Red-chested mustached tamarin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Saguinus.
OX   NCBI_TaxID=78454;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional coactivator of the p300/CBP-mediated
CC       transcription complex. Acts as a bridge, linking TFAP2 transcription
CC       factors and the p300/CBP transcriptional coactivator complex in order
CC       to stimulate TFAP2-mediated transcriptional activation. Positively
CC       regulates TGF-beta signaling through its association with the
CC       SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates
CC       the peroxisome proliferator-activated receptors PPARA transcriptional
CC       activity. Enhances estrogen-dependent transactivation mediated by
CC       estrogen receptors. Acts also as a transcriptional corepressor;
CC       interferes with the binding of the transcription factors HIF1A or STAT2
CC       and the p300/CBP transcriptional coactivator complex. Participates in
CC       sex determination and early gonad development by stimulating
CC       transcription activation of SRY. Plays a role in controlling left-right
CC       patterning during embryogenesis; potentiates transcriptional activation
CC       of NODAL-mediated gene transcription in the left lateral plate mesoderm
CC       (LPM). Plays an essential role in differentiation of the adrenal cortex
CC       from the adrenogonadal primordium (AGP); stimulates WT1-mediated
CC       transcription activation thereby up-regulating the nuclear hormone
CC       receptor NR5A1 promoter activity. Associates with chromatin to the
CC       PITX2 P1 promoter region.
CC   -!- SUBUNIT: Interacts (via C-terminus) with SMAD2. Interacts (via C-
CC       terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM
CC       domains). Interacts with WT1 (By similarity). Interacts (via C-
CC       terminus) with EP300 (via CH1 domain); the interaction is stimulated in
CC       response to hypoxia. Interacts with PPARA. Interacts (via C-terminus)
CC       with TFAP2A, TFAP2B and TFAP2C. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with
CC       EP300 in dot-like structures. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CITED family. {ECO:0000305}.
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DR   EMBL; DQ977048; ABM47759.1; -; Genomic_DNA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR   GO; GO:0035802; P:adrenal cortex formation; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:2000020; P:positive regulation of male gonad development; ISS:UniProtKB.
DR   GO; GO:0035360; P:positive regulation of peroxisome proliferator activated receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0003156; P:regulation of animal organ formation; ISS:UniProtKB.
DR   GO; GO:0043627; P:response to estrogen; ISS:UniProtKB.
DR   GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR   GO; GO:0007530; P:sex determination; ISS:UniProtKB.
DR   InterPro; IPR007576; CITED.
DR   PANTHER; PTHR17045; PTHR17045; 1.
DR   Pfam; PF04487; CITED; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Differentiation; Nucleus; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..273
FT                   /note="Cbp/p300-interacting transactivator 2"
FT                   /id="PRO_0000285516"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   273 AA;  28665 MW;  BE057C8A6FC2F1B8 CRC64;
     MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA LMGEHIHYGA
     GTMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMA PPVASQGGSL PASMQLQKLN
     NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG
     GSAGGGAGSS NSGGGSGGSG SSNMPASVAH VPAAMLPPNV IDTDFIDEEV LMSLVIXMGL
     DRIKELPELW LGQNEFDFMT DFVCKQQPSR VSC