ID   CITE2_XENTR             Reviewed;         225 AA.
AC   Q6NX30; Q28GT4;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Cbp/p300-interacting transactivator 2 {ECO:0000250|UniProtKB:Q99967};
GN   Name=cited2; ORFNames=TEgg144j19.1, TNeu124g09.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ82609.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg {ECO:0000312|EMBL:CAJ82068.1}, and
RC   Neurula {ECO:0000312|EMBL:CAJ82609.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ82609.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud {ECO:0000312|EMBL:AAH67308.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional coactivator or corepressor of the p300/CBP-
CC       mediated transcription complex. May be involved in sex determination,
CC       early gonad development, left-right patterning during embryogenesis and
CC       differentiation of the adrenal cortex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99967}.
CC   -!- SIMILARITY: Belongs to the CITED family. {ECO:0000255}.
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DR   EMBL; CR760080; CAJ82609.1; -; mRNA.
DR   EMBL; CR761235; CAJ82068.1; -; mRNA.
DR   EMBL; BC067308; AAH67308.1; -; mRNA.
DR   RefSeq; NP_001001196.1; NM_001001196.1.
DR   AlphaFoldDB; Q6NX30; -.
DR   STRING; 8364.ENSXETP00000011639; -.
DR   PaxDb; Q6NX30; -.
DR   GeneID; 407853; -.
DR   KEGG; xtr:407853; -.
DR   CTD; 10370; -.
DR   Xenbase; XB-GENE-495035; cited2.
DR   eggNOG; ENOG502QSRC; Eukaryota.
DR   HOGENOM; CLU_090678_1_0_1; -.
DR   InParanoid; Q6NX30; -.
DR   OMA; HELHPAN; -.
DR   OrthoDB; 1378769at2759; -.
DR   TreeFam; TF331915; -.
DR   Reactome; R-XTR-1234158; Regulation of gene expression by Hypoxia-inducible Factor.
DR   Reactome; R-XTR-8866907; Activation of the TFAP2 (AP-2) family of transcription factors.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000041066; Expressed in egg cell and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISS:UniProtKB.
DR   GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR   GO; GO:0060972; P:left/right pattern formation; IBA:GO_Central.
DR   GO; GO:0045787; P:positive regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007530; P:sex determination; IBA:GO_Central.
DR   InterPro; IPR007576; CITED.
DR   PANTHER; PTHR17045; PTHR17045; 1.
DR   Pfam; PF04487; CITED; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..225
FT                   /note="Cbp/p300-interacting transactivator 2"
FT                   /id="PRO_0000390736"
FT   CONFLICT        165
FT                   /note="A -> G (in Ref. 1; CAJ82068)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   225 AA;  25255 MW;  078D328D33AB6DF4 CRC64;
     MADHMMAMNH SRFQDGTNGL HHPAHRMGMG QFSNHHHHPQ QHTFNSLMGE HMHYGPGNIN
     ANNSIRHAIV TGNVNGGHPN GSMAPASRFN SPFMGPVPNQ GAQLTASMQL QKLNNQYFTH
     HPYPHNHYIP ELHPANQING TNQHFRDCNP KHSTGMPPSV SHVPAAMLPP SVIDTDFIDE
     EVLMSLVIEM GLDRIKELPE LWLGQNEFDF MTDFVCKQQP NRVSC