ID   CITE4_BOVIN             Reviewed;         185 AA.
AC   Q2HJ78;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Cbp/p300-interacting transactivator 4;
GN   Name=CITED4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as transcriptional coactivator for TFAP2/AP-2. Enhances
CC       estrogen-dependent transactivation mediated by estrogen receptors. May
CC       function as an inhibitor of transactivation by HIF1A by disrupting
CC       HIF1A interaction with CREBBP. May be involved in regulation of gene
CC       expression during development and differentiation of blood cells,
CC       endothelial cells and mammary epithelial cells (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts via its C-terminal region with the CH1 domain of
CC       CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CITED family. {ECO:0000305}.
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DR   EMBL; BC113266; AAI13267.1; -; mRNA.
DR   RefSeq; NP_001074195.1; NM_001080726.1.
DR   AlphaFoldDB; Q2HJ78; -.
DR   STRING; 9913.ENSBTAP00000020109; -.
DR   PaxDb; Q2HJ78; -.
DR   Ensembl; ENSBTAT00000020109; ENSBTAP00000020109; ENSBTAG00000015113.
DR   GeneID; 504742; -.
DR   KEGG; bta:504742; -.
DR   CTD; 163732; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015113; -.
DR   VGNC; VGNC:27378; CITED4.
DR   eggNOG; ENOG502QQEE; Eukaryota.
DR   GeneTree; ENSGT00530000063624; -.
DR   HOGENOM; CLU_128809_0_0_1; -.
DR   InParanoid; Q2HJ78; -.
DR   OMA; GPHALWT; -.
DR   OrthoDB; 1378769at2759; -.
DR   TreeFam; TF331915; -.
DR   Reactome; R-BTA-8866907; Activation of the TFAP2 (AP-2) family of transcription factors.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000015113; Expressed in parenchyma of mammary gland and 102 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0043627; P:response to estrogen; ISS:UniProtKB.
DR   InterPro; IPR007576; CITED.
DR   PANTHER; PTHR17045; PTHR17045; 1.
DR   Pfam; PF04487; CITED; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..185
FT                   /note="Cbp/p300-interacting transactivator 4"
FT                   /id="PRO_0000285517"
FT   REGION          15..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          95..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..126
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   185 AA;  18719 MW;  0313793D752D5749 CRC64;
     MADHLMLAEG YSLVPRPPPA APAHGPHALR TLQPYSSPGL DSGLRPRGAP LGPPPPPQGT
     VAYGAFGPSP TFQPFPAVPP PAAGNAHLQP VATLYPGRAT MPPGAPGGPS GPQPAPGAPA
     PPLQPPAHAL GGMDAELIDE EALTSLELEL GLHRVRDLPE LFLGQSEFDC FSDLGSAPPA
     GSVSC