CITE4_HUMAN
ID CITE4_HUMAN Reviewed; 184 AA.
AC Q96RK1;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Cbp/p300-interacting transactivator 4;
DE AltName: Full=MSG1-related protein 2;
DE Short=MRG-2;
GN Name=CITED4 {ECO:0000312|HGNC:HGNC:18696}; Synonyms=MRG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAK64235.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zhuang D.Z., Chou Y.-T., Yang Y.-C.;
RT "Structural and functional conservation of MRG family in system
RT evolution.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAL73989.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH CREBBP; EP300
RP AND TFAP2, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11744733; DOI=10.1074/jbc.m110850200;
RA Braganca J., Swingler T., Marques F.I.R., Jones T., Eloranta J.J.,
RA Hurst H.C., Shioda T., Bhattacharya S.;
RT "Human CREB-binding protein/p300-interacting transactivator with ED-rich
RT tail (CITED) 4, a new member of the CITED family, functions as a co-
RT activator for transcription factor AP-2.";
RL J. Biol. Chem. 277:8559-8565(2002).
RN [3] {ECO:0000312|EMBL:AAH35496.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas {ECO:0000312|EMBL:AAH35496.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15342390; DOI=10.1158/0008-5472.can-04-0708;
RA Fox S.B., Braganca J., Turley H., Campo L., Han C., Gatter K.C.,
RA Bhattacharya S., Harris A.L.;
RT "CITED4 inhibits hypoxia-activated transcription in cancer cells, and its
RT cytoplasmic location in breast cancer is associated with elevated
RT expression of tumor cell hypoxia-inducible factor 1alpha.";
RL Cancer Res. 64:6075-6081(2004).
CC -!- FUNCTION: Acts as transcriptional coactivator for TFAP2/AP-2. Enhances
CC estrogen-dependent transactivation mediated by estrogen receptors. May
CC function as an inhibitor of transactivation by HIF1A by disrupting
CC HIF1A interaction with CREBBP. May be involved in regulation of gene
CC expression during development and differentiation of blood cells,
CC endothelial cells and mammary epithelial cells.
CC {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}.
CC -!- SUBUNIT: Interacts via its C-terminal region with the CH1 domain of
CC CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms.
CC {ECO:0000269|PubMed:11744733}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11744733,
CC ECO:0000269|PubMed:15342390}. Cytoplasm {ECO:0000269|PubMed:11744733,
CC ECO:0000269|PubMed:15342390}.
CC -!- TISSUE SPECIFICITY: Expressed in most tissues examined with highest
CC levels of expression in heart, liver, skeletal muscle and pancreas.
CC Also expressed in bladder cell line ECV-304 and in various breast
CC cancer cell lines. Also detected in both in situ and invasive breast
CC tumors where its expression is down-regulated and mostly restricted to
CC the cytoplasm of malignant epithelium. Down-regulation of expression is
CC associated with elevated levels of HIF1A and increased tumor growth and
CC angiogenesis. {ECO:0000269|PubMed:11744733,
CC ECO:0000269|PubMed:15342390}.
CC -!- SIMILARITY: Belongs to the CITED family. {ECO:0000255}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/CITED4ID44535ch1p34.html";
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DR EMBL; AF362074; AAK64235.1; -; Genomic_DNA.
DR EMBL; AF466291; AAL73989.1; -; Genomic_DNA.
DR EMBL; BC052559; AAH52559.1; -; mRNA.
DR EMBL; BC035496; AAH35496.1; -; mRNA.
DR CCDS; CCDS458.1; -.
DR RefSeq; NP_597724.1; NM_133467.2.
DR AlphaFoldDB; Q96RK1; -.
DR BioGRID; 127875; 5.
DR STRING; 9606.ENSP00000361721; -.
DR BioMuta; CITED4; -.
DR DMDM; 74732696; -.
DR EPD; Q96RK1; -.
DR MassIVE; Q96RK1; -.
DR MaxQB; Q96RK1; -.
DR PaxDb; Q96RK1; -.
DR PeptideAtlas; Q96RK1; -.
DR PRIDE; Q96RK1; -.
DR ProteomicsDB; 77974; -.
DR TopDownProteomics; Q96RK1; -.
DR Antibodypedia; 32148; 144 antibodies from 24 providers.
DR DNASU; 163732; -.
DR Ensembl; ENST00000372638.4; ENSP00000361721.2; ENSG00000179862.7.
DR GeneID; 163732; -.
DR KEGG; hsa:163732; -.
DR MANE-Select; ENST00000372638.4; ENSP00000361721.2; NM_133467.3; NP_597724.1.
DR UCSC; uc001cgj.4; human.
DR CTD; 163732; -.
DR DisGeNET; 163732; -.
DR GeneCards; CITED4; -.
DR HGNC; HGNC:18696; CITED4.
DR HPA; ENSG00000179862; Low tissue specificity.
DR MIM; 606815; gene.
DR neXtProt; NX_Q96RK1; -.
DR OpenTargets; ENSG00000179862; -.
DR PharmGKB; PA38643; -.
DR VEuPathDB; HostDB:ENSG00000179862; -.
DR eggNOG; ENOG502QQEE; Eukaryota.
DR GeneTree; ENSGT00530000063624; -.
DR HOGENOM; CLU_128809_0_0_1; -.
DR InParanoid; Q96RK1; -.
DR OMA; GPHALWT; -.
DR OrthoDB; 1378769at2759; -.
DR PhylomeDB; Q96RK1; -.
DR TreeFam; TF331915; -.
DR PathwayCommons; Q96RK1; -.
DR Reactome; R-HSA-8866907; Activation of the TFAP2 (AP-2) family of transcription factors.
DR SignaLink; Q96RK1; -.
DR BioGRID-ORCS; 163732; 15 hits in 1068 CRISPR screens.
DR ChiTaRS; CITED4; human.
DR GenomeRNAi; 163732; -.
DR Pharos; Q96RK1; Tbio.
DR PRO; PR:Q96RK1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96RK1; protein.
DR Bgee; ENSG00000179862; Expressed in olfactory segment of nasal mucosa and 128 other tissues.
DR Genevisible; Q96RK1; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0043627; P:response to estrogen; ISS:UniProtKB.
DR InterPro; IPR007576; CITED.
DR PANTHER; PTHR17045; PTHR17045; 1.
DR Pfam; PF04487; CITED; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..184
FT /note="Cbp/p300-interacting transactivator 4"
FT /id="PRO_0000233309"
FT REGION 18..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..124
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 184 AA; 18569 MW; 6775E3F2F0C25F10 CRC64;
MADHLMLAEG YRLVQRPPSA AAAHGPHALR TLPPYAGPGL DSGLRPRGAP LGPPPPRQPG
ALAYGAFGPP SSFQPFPAVP PPAAGIAHLQ PVATPYPGRA AAPPNAPGGP PGPQPAPSAA
APPPPAHALG GMDAELIDEE ALTSLELELG LHRVRELPEL FLGQSEFDCF SDLGSAPPAG
SVSC
