ID   CITE4_RAT               Reviewed;         179 AA.
AC   Q99MA0;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Cbp/p300-interacting transactivator 4;
DE   AltName: Full=MSG1-related protein 2;
DE            Short=MRG-2;
GN   Name=Cited4 {ECO:0000312|RGD:620113}; Synonyms=Mrg2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAK30622.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAK30622.1};
RC   TISSUE=Heart {ECO:0000312|EMBL:AAK30622.1};
RA   Zhuang D.Z., Chou Y.-T., Yang Y.-C.;
RT   "Structural and functional conservation of MRG family in system
RT   evolution.";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as transcriptional coactivator for TFAP2/AP-2. Enhances
CC       estrogen-dependent transactivation mediated by estrogen receptors. May
CC       function as an inhibitor of transactivation by HIF1A by disrupting
CC       HIF1A interaction with CREBBP. May be involved in regulation of gene
CC       expression during development and differentiation of blood cells,
CC       endothelial cells and mammary epithelial cells (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts via its C-terminal region with the CH1 domain of
CC       CREBBP and EP300. Interacts with all TFAP2/AP-2 isoforms (By
CC       similarity). {ECO:0000250|UniProtKB:Q96RK1,
CC       ECO:0000250|UniProtKB:Q9WUL8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q96RK1}.
CC   -!- SIMILARITY: Belongs to the CITED family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF361477; AAK30622.1; -; mRNA.
DR   RefSeq; NP_446151.1; NM_053699.1.
DR   AlphaFoldDB; Q99MA0; -.
DR   STRING; 10116.ENSRNOP00000064826; -.
DR   PaxDb; Q99MA0; -.
DR   Ensembl; ENSRNOT00000072427; ENSRNOP00000064826; ENSRNOG00000046607.
DR   GeneID; 114491; -.
DR   KEGG; rno:114491; -.
DR   UCSC; RGD:620113; rat.
DR   CTD; 163732; -.
DR   RGD; 620113; Cited4.
DR   eggNOG; ENOG502QQEE; Eukaryota.
DR   GeneTree; ENSGT00530000063624; -.
DR   HOGENOM; CLU_128809_0_0_1; -.
DR   InParanoid; Q99MA0; -.
DR   OMA; GPHALWT; -.
DR   OrthoDB; 1378769at2759; -.
DR   PhylomeDB; Q99MA0; -.
DR   PRO; PR:Q99MA0; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000046607; Expressed in skeletal muscle tissue and 19 other tissues.
DR   Genevisible; Q99MA0; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR   GO; GO:0043627; P:response to estrogen; ISS:UniProtKB.
DR   InterPro; IPR007576; CITED.
DR   PANTHER; PTHR17045; PTHR17045; 1.
DR   Pfam; PF04487; CITED; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..179
FT                   /note="Cbp/p300-interacting transactivator 4"
FT                   /id="PRO_0000233311"
FT   REGION          23..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..122
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   179 AA;  18158 MW;  7B1A819DE7865284 CRC64;
     MADHLMLAEG YCLLQVPHAP RTLQPYPGPG LDSGLRPRGA PLGPPPPSGT LAYGSFGSPV
     SFQPFPVSQP PGAGNAHLQS AATPSPGRMP APPSAAGGPS PLQPAPGAAS PLPLPPPPPL
     PPALGCMDAE LIDEEALTSL ELELGLHRVR ELPELFLGQS EFDCFSDLGS VPAAGSVSC