ACHA6_CHICK
ID ACHA6_CHICK Reviewed; 494 AA.
AC P49581; Q90709;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Neuronal acetylcholine receptor subunit alpha-6;
DE Flags: Precursor;
GN Name=CHRNA6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn;
RA Alliod C., Ballivet M.;
RL Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9203638; DOI=10.1124/mol.51.2.320;
RA Gerzanich V., Kuryatov A., Anand R., Lindstrom J.;
RT "'Orphan' alpha6 nicotinic AChR subunit can form a functional heteromeric
RT acetylcholine receptor.";
RL Mol. Pharmacol. 51:320-327(1997).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC -!- SUBUNIT: Neuronal AChR seems to be composed of two different type of
CC subunits: alpha and non-alpha (also called beta). A functional receptor
CC seems to consist of two alpha-chains and three non-alpha chains.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; X83889; CAA58766.1; -; mRNA.
DR EMBL; U48860; AAA92122.1; -; mRNA.
DR PIR; T09289; T09289.
DR RefSeq; NP_990695.1; NM_205364.1.
DR AlphaFoldDB; P49581; -.
DR SMR; P49581; -.
DR ComplexPortal; CPX-201; Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3.
DR ComplexPortal; CPX-214; Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4.
DR STRING; 9031.ENSGALP00000036997; -.
DR BindingDB; P49581; -.
DR PaxDb; P49581; -.
DR GeneID; 396321; -.
DR KEGG; gga:396321; -.
DR CTD; 8973; -.
DR VEuPathDB; HostDB:geneid_396321; -.
DR eggNOG; KOG3645; Eukaryota.
DR InParanoid; P49581; -.
DR OrthoDB; 381858at2759; -.
DR PhylomeDB; P49581; -.
DR PRO; PR:P49581; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IC:ComplexPortal.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051899; P:membrane depolarization; IC:ComplexPortal.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..494
FT /note="Neuronal acetylcholine receptor subunit alpha-6"
FT /id="PRO_0000000364"
FT TOPO_DOM 32..240
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..468
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 364..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..390
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 158..172
FT /evidence="ECO:0000250"
FT CONFLICT 97
FT /note="R -> W (in Ref. 2; CAA58766/AAA92122)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 494 AA; 57495 MW; 195C9B2D27B86025 CRC64;
MHPKRRLCWC LPASGAWAFM LTSLIADTTA CESEERLFHK LFSRYNQFIR PVENVSDPVT
VHFELAITQL TNVDEVNQIM ETNLWLRHIW NDYKLRRDPR EYDGIEFVRV PADKIWKPDI
VLYNNAVGDF QVEGKTKALL RYDGMITWTP PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT
YDKAKIDLLI IGSKVDMNEF WENSEWEIVD ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP
MFYTINLIIP CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVI
PLVGEYLLFT MIFVTLSIVI TVFVLNIHYR TPTTHTMPKW VKTVFLSLLP KVLLMQRPLE
QEKKNISKKT KKGSAKTSGK SKHSKHKDNK LHKEQRCCHC DKADDLTSTR RSRLSHQSLK
WMAEHTEYSP EVKDVINNVQ FIAENMKSQN ETKEVEDDWK YVAMVIDRVF LWVFIILCVF
GTAGLFIQPL IADT
