ID   CITG_STRPD              Reviewed;         294 AA.
AC   Q1JGR7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase {ECO:0000255|HAMAP-Rule:MF_00397};
DE            Short=2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase {ECO:0000255|HAMAP-Rule:MF_00397};
DE            EC=2.4.2.52 {ECO:0000255|HAMAP-Rule:MF_00397};
GN   Name=citG {ECO:0000255|HAMAP-Rule:MF_00397};
GN   OrderedLocusNames=MGAS10270_Spy1012;
OS   Streptococcus pyogenes serotype M2 (strain MGAS10270).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=370552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS10270;
RX   PubMed=16636287; DOI=10.1073/pnas.0510279103;
RA   Beres S.B., Richter E.W., Nagiec M.J., Sumby P., Porcella S.F., DeLeo F.R.,
RA   Musser J.M.;
RT   "Molecular genetic anatomy of inter- and intraserotype variation in the
RT   human bacterial pathogen group A Streptococcus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7059-7064(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-
CC         3'-dephospho-CoA + adenine; Xref=Rhea:RHEA:15117, ChEBI:CHEBI:16708,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:57328, ChEBI:CHEBI:61378; EC=2.4.2.52;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00397};
CC   -!- SIMILARITY: Belongs to the CitG/MdcB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00397}.
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DR   EMBL; CP000260; ABF34077.1; -; Genomic_DNA.
DR   RefSeq; WP_020905202.1; NC_008022.1.
DR   AlphaFoldDB; Q1JGR7; -.
DR   EnsemblBacteria; ABF34077; ABF34077; MGAS10270_Spy1012.
DR   KEGG; sph:MGAS10270_Spy1012; -.
DR   HOGENOM; CLU_056179_1_0_9; -.
DR   OMA; QSWQRPA; -.
DR   Proteomes; UP000002436; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046917; F:triphosphoribosyl-dephospho-CoA synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:InterPro.
DR   HAMAP; MF_00397; CitG; 1.
DR   InterPro; IPR002736; CitG.
DR   InterPro; IPR017551; TriPribosyl-deP-CoA_syn_CitG.
DR   PANTHER; PTHR30201; PTHR30201; 1.
DR   Pfam; PF01874; CitG; 1.
DR   TIGRFAMs; TIGR03125; citrate_citG; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Transferase.
FT   CHAIN           1..294
FT                   /note="Probable 2-(5''-triphosphoribosyl)-3'-
FT                   dephosphocoenzyme-A synthase"
FT                   /id="PRO_0000255417"
SQ   SEQUENCE   294 AA;  32818 MW;  788C7B505AAA8A8B CRC64;
     MTKAVLTSIS QLALKALLYE VSLSPKPGLV DRFDNGAHDD MSFMTFIDSM IALSPFFQAY
     IETGFAYAKE EPLLLFNRLR QLGQKAEETM FCATQGINTH KGLNFSMALL LGTTGAYLAR
     TPHLMTDLGR FSKEDTLAIC RLVKPMTAHL IQTDLGHLNT KKEFTYGEQL FVTYGIKGPR
     GEASEGFTTL TDHALPYFRQ MISQNDPETS QLRLLVYLMS IVEDGNLIHR GGIEAWKGVK
     ADMRLLLQQD LSTTDLRLAL SSYNQCLINQ HLSPGGAADL LALTFYFAFL EKLL