ACHA6_PANTR
ID ACHA6_PANTR Reviewed; 494 AA.
AC Q5IS76;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Neuronal acetylcholine receptor subunit alpha-6;
DE Flags: Precursor;
GN Name=CHRNA6;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT "Accelerated evolution of nervous system genes in the origin of Homo
RT sapiens.";
RL Cell 119:1027-1040(2004).
CC -!- FUNCTION: After binding acetylcholine, the AChR responds by an
CC extensive change in conformation that affects all subunits and leads to
CC opening of an ion-conducting channel across the plasma membrane.
CC {ECO:0000250}.
CC -!- SUBUNIT: Neuronal AChR seems to be composed of two different types of
CC subunits: alpha and non-alpha (beta). Interacts with LYPD6.
CC {ECO:0000250|UniProtKB:Q15825}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; AY665252; AAV74290.1; -; mRNA.
DR RefSeq; NP_001029266.1; NM_001034094.1.
DR AlphaFoldDB; Q5IS76; -.
DR SMR; Q5IS76; -.
DR STRING; 9598.ENSPTRP00000034613; -.
DR PaxDb; Q5IS76; -.
DR GeneID; 472750; -.
DR KEGG; ptr:472750; -.
DR CTD; 8973; -.
DR eggNOG; KOG3645; Eukaryota.
DR HOGENOM; CLU_018074_1_0_1; -.
DR InParanoid; Q5IS76; -.
DR OrthoDB; 381858at2759; -.
DR TreeFam; TF315605; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; ISS:UniProtKB.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0015464; F:acetylcholine receptor activity; ISS:UniProtKB.
DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; ISS:UniProtKB.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0035095; P:behavioral response to nicotine; ISS:UniProtKB.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
DR GO; GO:0060084; P:synaptic transmission involved in micturition; ISS:UniProtKB.
DR Gene3D; 1.20.58.390; -; 2.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Phosphoprotein;
KW Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..494
FT /note="Neuronal acetylcholine receptor subunit alpha-6"
FT /id="PRO_0000000362"
FT TOPO_DOM 26..239
FT /note="Extracellular"
FT TRANSMEM 240..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..465
FT /note="Cytoplasmic"
FT TRANSMEM 466..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 401
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P04757"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 158..172
FT /evidence="ECO:0000250"
FT DISULFID 222..223
FT /note="Associated with receptor activation"
FT /evidence="ECO:0000250"
SQ SEQUENCE 494 AA; 56921 MW; A5480CBC4FB98531 CRC64;
MLTSKGQGFL HGGLCLWLCV FTPFFKGCVG CATEERLFHK LFSHYNQFIR PVENVSDPVT
VHFEVAITQL ANVDEVNQIM ETNLWLRHIW NDYKLRWDPM EYDGIETLRI PADKIWKPDI
VLYNNAVGDF QVEGKTKALL KYNGMITWTP PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT
YDKAEIDLLI IGSKVDMNDF WENSEWEIID ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP
MFYTINLIIP CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVV
PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPTTHTMPRW VKTVFLKLLP QVLLMRWPLD
KTRGTGSDAV PRGLARRPAK GKLASHGEPR HLKECFHCHK SNELATSKRR LSHHPLQWVV
ENSEHSPEVE DVINSVQFIA ENMKSHNETK EVEDDWKYVA MVVDRVFLWV FIIVCVFGTA
GLFLQPLLGN TGKS
