CITN_LACLL
ID CITN_LACLL Reviewed; 442 AA.
AC P21608;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Citrate-sodium symporter;
DE AltName: Full=Citrate carrier protein;
DE AltName: Full=Citrate transporter;
GN Name=citP;
OS Lactococcus lactis subsp. lactis (Streptococcus lactis).
OG Plasmid pCT176.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=1360;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Diacetylactis / DSM 20661 / NCDO 176;
RX PubMed=2120190; DOI=10.1128/jb.172.10.5789-5794.1990;
RA David S., van der Rest M.E., Driessen A.J.M., Simons G., de Vos W.M.;
RT "Nucleotide sequence and expression in Escherichia coli of the Lactococcus
RT lactis citrate permease gene.";
RL J. Bacteriol. 172:5789-5794(1990).
CC -!- FUNCTION: Uptake of citrate across the boundary membrane with the
CC concomitant uptake of a sodium ion (symport system).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the sodium:citrate (SCF) symporter family.
CC {ECO:0000305}.
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DR EMBL; M58694; AAA25165.1; -; Genomic_DNA.
DR PIR; A36136; A36136.
DR RefSeq; NP_258266.1; NC_003101.1.
DR RefSeq; WP_010976688.1; NZ_WJUM01000051.1.
DR RefSeq; YP_005869744.1; NC_017489.1.
DR AlphaFoldDB; P21608; -.
DR SMR; P21608; -.
DR TCDB; 2.A.24.3.1; the 2-hydroxycarboxylate transporter (2-hct) family.
DR PRO; PR:P21608; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006101; P:citrate metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR018025; 2-OHcarbox_trans_Prot/Firm.
DR InterPro; IPR004679; 2-OHcarboxylate_transport.
DR PANTHER; PTHR40033; PTHR40033; 1.
DR Pfam; PF03390; 2HCT; 1.
DR PIRSF; PIRSF005348; YxkH; 1.
DR TIGRFAMs; TIGR00783; ccs; 1.
PE 3: Inferred from homology;
KW Cell membrane; Citrate utilization; Membrane; Plasmid; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..442
FT /note="Citrate-sodium symporter"
FT /id="PRO_0000088756"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 442 AA; 46629 MW; 58A2296B498155D3 CRC64;
MMNHPHSSHI GTTNVKEEIG KLDRIRISGI GLIAYAFMAV LLIIAISTKT LPNTMIGAIF
ALVLMGHVFY YLGAHLPIFR SYLGGGSVFT ILLTAILVAT NVIPKYVVTT ASGFINGMDF
LGLYIVSLIA SSLFKMDRKM LLKAAVRFLP VAFISMALTA VVIGIVGVII GVGFNYAILY
IAMPIMAGGV GAGIVPLSGI YAHAMGVGSA GILSKLFPTV ILGNLLAIIS AGLISRIFKD
SKGNGHGEIL RGEREKSAAA EEIKPDYVQL GVGLIIAVMF FMIGTMLNKV FPGINAYAFI
ILSIVLTKAF GLLPKYYEDS VIMFGQVIVK NMTHALLAGV GLSLLDMHVL LAALSWQFVV
LCLVSIVAIS LISATLGKLF GLYPVEAAIT AGLANNSMGG TGNVAVLAAS ERMNLIAFAQ
MGNRIGGALI LVVAGILVTF MK
