ID   CITN_SALTI              Reviewed;         446 AA.
AC   P0A2F9; P31604;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Citrate-sodium symporter;
DE   AltName: Full=Citrate carrier protein;
DE   AltName: Full=Citrate transporter;
GN   Name=citP; Synonyms=citC; OrderedLocusNames=STY0066, t0059;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Uptake of citrate across the boundary membrane with the
CC       concomitant uptake of a sodium ion (symport system). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sodium:citrate (SCF) symporter family.
CC       {ECO:0000305}.
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DR   EMBL; AL513382; CAD01212.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO67792.1; -; Genomic_DNA.
DR   PIR; AD0509; AD0509.
DR   RefSeq; NP_454668.1; NC_003198.1.
DR   RefSeq; WP_000183602.1; NZ_WSUR01000028.1.
DR   AlphaFoldDB; P0A2F9; -.
DR   SMR; P0A2F9; -.
DR   STRING; 220341.16501341; -.
DR   EnsemblBacteria; AAO67792; AAO67792; t0059.
DR   KEGG; stt:t0059; -.
DR   KEGG; sty:STY0066; -.
DR   PATRIC; fig|220341.7.peg.66; -.
DR   eggNOG; COG3493; Bacteria.
DR   HOGENOM; CLU_041211_0_1_6; -.
DR   OMA; NMGGTGD; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008514; F:organic anion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006101; P:citrate metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR018025; 2-OHcarbox_trans_Prot/Firm.
DR   InterPro; IPR004679; 2-OHcarboxylate_transport.
DR   PANTHER; PTHR40033; PTHR40033; 1.
DR   Pfam; PF03390; 2HCT; 1.
DR   PIRSF; PIRSF005348; YxkH; 1.
DR   TIGRFAMs; TIGR00783; ccs; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Citrate utilization; Membrane; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..446
FT                   /note="Citrate-sodium symporter"
FT                   /id="PRO_0000088759"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   446 AA;  47622 MW;  58A22E78AC7F4121 CRC64;
     MTNMTQASAT EKKGASDLLR FKIFGMPLPL YAFALITLLL SHFYNAIPTD LVGGFALMFV
     MGAIFGEIGK RLPIFNKYIG GAPVMIFLVA AYFVYAGIFT QKEIDAISNV MDKSNFLNLF
     IAVLITGAIL SVNRKLLLKS LLGYIPTILA GIVGASLFGI VIGLCFGIPV DRIMMLYVLP
     IMGGGNGAGA VPLSEIYHSV TGRSREEYYS TAIAILTIAN IFAIIFAALL DMIGKKYTWL
     SGEGELVRKA SFKTEDDEKA GQITHRETAV GMVLSTTCFL LAYVVAKKIL PSIGGVSIHY
     FAWMVLIVAA LNASGLCSPE IKAGAKRLSD FFSKQLLWVL MVGVGVCYTD LQEIIDALTF
     ANVVIAAIIV VGAVVGAAIG GWLIGFYPIE SSITAGLCMA NRGGSGDLEV LSACNRMNLI
     SYAQISSRLG GGIVLVIASI VFSMMV