CITT_ECO57
ID CITT_ECO57 Reviewed; 487 AA.
AC P0AE75; P77405;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Citrate/succinate antiporter;
DE AltName: Full=Citrate carrier;
DE AltName: Full=Citrate transporter;
GN Name=citT; OrderedLocusNames=Z0756, ECs0651;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Responsible for the uptake of citrate in exchange to the
CC efflux of succinate. Has a relatively broad specificity for C(4)-
CC dicarboxylates and tricarboxylates (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC DIT1 subfamily. {ECO:0000305}.
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DR EMBL; AE005174; AAG54947.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34074.1; -; Genomic_DNA.
DR PIR; C90710; C90710.
DR RefSeq; NP_308678.1; NC_002695.1.
DR RefSeq; WP_000050323.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P0AE75; -.
DR SMR; P0AE75; -.
DR STRING; 155864.EDL933_0685; -.
DR EnsemblBacteria; AAG54947; AAG54947; Z0756.
DR EnsemblBacteria; BAB34074; BAB34074; ECs_0651.
DR GeneID; 66671113; -.
DR GeneID; 917010; -.
DR KEGG; ece:Z0756; -.
DR KEGG; ecs:ECs_0651; -.
DR PATRIC; fig|386585.9.peg.762; -.
DR eggNOG; COG0471; Bacteria.
DR HOGENOM; CLU_005170_7_0_6; -.
DR OMA; GLNPNAW; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR030676; CitT-rel.
DR InterPro; IPR001898; SLC13A/DASS.
DR PANTHER; PTHR42826; PTHR42826; 1.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR PIRSF; PIRSF002457; DASS; 1.
DR TIGRFAMs; TIGR00785; dass; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..487
FT /note="Citrate/succinate antiporter"
FT /id="PRO_0000172522"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 487 AA; 53093 MW; 9AD55B9E7448F1DB CRC64;
MSLAKDNIWK LLAPLVVMGV MFLIPVPDGM PPQAWHYFAV FVAMIVGMIL EPIPATAISF
IAVTICVIGS NYLLFDAKEL ADPAFNAQKQ ALKWGLAGFS STTVWLVFGA FIFALGYEVS
GLGRRIALFL VKFMGKRTLT LGYAIVIIDI LLAPFTPSNT ARTGGTVFPV IKNLPPLFKS
FPNDPSARRI GGYLMWMMVI STSLSSSMFV TGAAPNVLGL EFVSKIAGIQ ISWLQWFLCF
LPVGVILLII APWLSYVLYK PEITHSEEVA TWAGDELKTM GALTRREWTL IGLVLLSLGL
WVFGSEVINA TAVGLLAVSL MLALHVVPWK DITRYNSAWN TLVNLATLVV MANGLTRSGF
IDWFAGTMST HLEGFSPNAT VIVLVLVFYF AHYLFASLSA HTATMLPVIL AVGKGIPGVP
MEQLCILLVL SIGIMGCLTP YATGPGVIIY GCGYVKSKDY WRLGAIFGVI YISMLLLVGW
PILAMWN
