ID   CITX_STRP1              Reviewed;         192 AA.
AC   P58160; Q48YP6;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase;
DE            EC=2.7.7.61;
DE   AltName: Full=Apo-ACP nucleodityltransferase;
DE   AltName: Full=Holo-ACP synthase;
DE   AltName: Full=Holo-citrate lyase synthase;
GN   Name=citX; OrderedLocusNames=SPy_1190, M5005_Spy0908;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on
CC       a serine residue to the apo-acyl carrier protein (gamma chain) of the
CC       citrate lyase to yield holo-acyl carrier protein. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-
CC         [citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP];
CC         Xref=Rhea:RHEA:16333, Rhea:RHEA-COMP:10157, Rhea:RHEA-COMP:10158,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:33019, ChEBI:CHEBI:61378,
CC         ChEBI:CHEBI:82683; EC=2.7.7.61;
CC   -!- SIMILARITY: Belongs to the CitX family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAZ51526.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE004092; AAK34054.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51526.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_269333.1; NC_002737.2.
DR   AlphaFoldDB; P58160; -.
DR   SMR; P58160; -.
DR   PaxDb; P58160; -.
DR   EnsemblBacteria; AAK34054; AAK34054; SPy_1190.
DR   KEGG; spy:SPy_1190; -.
DR   KEGG; spz:M5005_Spy0908; -.
DR   PATRIC; fig|160490.10.peg.1040; -.
DR   HOGENOM; CLU_104529_1_0_9; -.
DR   OMA; CGRSRKH; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0050519; F:holo-citrate lyase synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051191; P:prosthetic group biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00398; CitX; 1.
DR   InterPro; IPR005551; CitX.
DR   Pfam; PF03802; CitX; 1.
DR   TIGRFAMs; TIGR03124; citrate_citX; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..192
FT                   /note="Probable apo-citrate lyase phosphoribosyl-dephospho-
FT                   CoA transferase"
FT                   /id="PRO_0000214688"
SQ   SEQUENCE   192 AA;  21618 MW;  5F315E4A2593CFE4 CRC64;
     MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP IKTSPKLLEA
     FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSR DLKLKMIALE TELPIGRLMD
     LDVLVLQNDL PHSISRTVLG GSPRQCFICS KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN
     KDNQSSSSDK TG