CJ053_HUMAN
ID CJ053_HUMAN Reviewed; 93 AA.
AC Q8N6V4; A6NI81; A6NLE0; B9ZVK6;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 3.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=UPF0728 protein C10orf53;
GN Name=C10orf53;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Brain, and Medulla oblongata;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8N6V4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N6V4-2; Sequence=VSP_036509;
CC Name=3;
CC IsoId=Q8N6V4-3; Sequence=VSP_036867;
CC Name=4;
CC IsoId=Q8N6V4-4; Sequence=VSP_046396;
CC -!- SIMILARITY: Belongs to the UPF0728 family. {ECO:0000305}.
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DR EMBL; AK091773; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC069546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471187; EAW93083.1; -; Genomic_DNA.
DR EMBL; CH471187; EAW93085.1; -; Genomic_DNA.
DR EMBL; BC028127; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BI825648; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS31202.1; -. [Q8N6V4-4]
DR CCDS; CCDS41521.1; -. [Q8N6V4-1]
DR RefSeq; NP_001035892.1; NM_001042427.1. [Q8N6V4-1]
DR RefSeq; NP_872360.2; NM_182554.2. [Q8N6V4-4]
DR AlphaFoldDB; Q8N6V4; -.
DR BioGRID; 129425; 16.
DR STRING; 9606.ENSP00000363226; -.
DR iPTMnet; Q8N6V4; -.
DR BioMuta; C10orf53; -.
DR DMDM; 224471890; -.
DR MassIVE; Q8N6V4; -.
DR PeptideAtlas; Q8N6V4; -.
DR PRIDE; Q8N6V4; -.
DR ProteomicsDB; 72239; -. [Q8N6V4-1]
DR ProteomicsDB; 72240; -. [Q8N6V4-2]
DR ProteomicsDB; 72241; -. [Q8N6V4-3]
DR ProteomicsDB; 7546; -.
DR Antibodypedia; 50326; 36 antibodies from 10 providers.
DR DNASU; 282966; -.
DR Ensembl; ENST00000374111.8; ENSP00000363225.3; ENSG00000178645.13. [Q8N6V4-1]
DR Ensembl; ENST00000374112.7; ENSP00000363226.3; ENSG00000178645.13. [Q8N6V4-4]
DR Ensembl; ENST00000374113.3; ENSP00000363227.3; ENSG00000178645.13. [Q8N6V4-2]
DR Ensembl; ENST00000535836.1; ENSP00000437726.1; ENSG00000178645.13. [Q8N6V4-4]
DR GeneID; 282966; -.
DR KEGG; hsa:282966; -.
DR MANE-Select; ENST00000374111.8; ENSP00000363225.3; NM_001042427.3; NP_001035892.1.
DR UCSC; uc001jib.4; human. [Q8N6V4-1]
DR CTD; 282966; -.
DR DisGeNET; 282966; -.
DR GeneCards; C10orf53; -.
DR HGNC; HGNC:27421; C10orf53.
DR HPA; ENSG00000178645; Tissue enriched (testis).
DR neXtProt; NX_Q8N6V4; -.
DR OpenTargets; ENSG00000178645; -.
DR PharmGKB; PA134895627; -.
DR VEuPathDB; HostDB:ENSG00000178645; -.
DR GeneTree; ENSGT00390000002871; -.
DR HOGENOM; CLU_189555_0_0_1; -.
DR InParanoid; Q8N6V4; -.
DR OMA; VEHRTYR; -.
DR OrthoDB; 1360311at2759; -.
DR PhylomeDB; Q8N6V4; -.
DR TreeFam; TF329673; -.
DR PathwayCommons; Q8N6V4; -.
DR BioGRID-ORCS; 282966; 10 hits in 1038 CRISPR screens.
DR ChiTaRS; C10orf53; human.
DR GenomeRNAi; 282966; -.
DR Pharos; Q8N6V4; Tdark.
DR PRO; PR:Q8N6V4; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8N6V4; protein.
DR Bgee; ENSG00000178645; Expressed in sperm and 30 other tissues.
DR Genevisible; Q8N6V4; HS.
DR InterPro; IPR027885; UPF0728.
DR PANTHER; PTHR28448; PTHR28448; 1.
DR Pfam; PF15092; UPF0728; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..93
FT /note="UPF0728 protein C10orf53"
FT /id="PRO_0000089794"
FT VAR_SEQ 74..93
FT /note="GDGKLDPLCEKARIAVLNAY -> KPFGDASSQQFASSEESLNF (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036509"
FT VAR_SEQ 74..93
FT /note="GDGKLDPLCEKARIAVLNAY -> KLTPSSDKRTTSSSRLTFHQLSSPCGMK
FT VSPLQQFPQKTQDLTCIVLAQIGSCIHFQTNLCDLGWPGLDHMLISGLEKRGTQPY
FT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_036867"
FT VAR_SEQ 74..93
FT /note="GDGKLDPLCEKARIAVLNAY -> KLTPSSDKRTTSSSRLTFHQLSSPCRMK
FT VSPLQQFPQKTQDLTCTVLAQIGSCIHFQTNLCDLGWPGLDHMLISGLEKRGTQPY
FT (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046396"
FT CONFLICT Q8N6V4-4:99
FT /note="R -> G (in Ref. 4; BI825648)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 93 AA; 10399 MW; 0C706BDA1A4E238E CRC64;
MPKNAVVILR YGPYSAAGLP VEHHTFRLQG LQAVLAIDGH EVILEKIEDW NVVELMVNEE
VIFHCNIKDL EFGGDGKLDP LCEKARIAVL NAY
