CJ062_HUMAN
ID CJ062_HUMAN Reviewed; 223 AA.
AC Q5T681; Q49A70; Q8N3Y6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Uncharacterized protein C10orf62;
GN Name=C10orf62;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-121.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5T681; P51116: FXR2; NbExp=4; IntAct=EBI-744052, EBI-740459;
CC Q5T681; Q6A162: KRT40; NbExp=3; IntAct=EBI-744052, EBI-10171697;
CC Q5T681; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-744052, EBI-11959885;
CC Q5T681; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-744052, EBI-10171774;
CC Q5T681; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-744052, EBI-10172052;
CC Q5T681; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-744052, EBI-3958099;
CC Q5T681; Q99750: MDFI; NbExp=7; IntAct=EBI-744052, EBI-724076;
CC Q5T681; Q99471: PFDN5; NbExp=3; IntAct=EBI-744052, EBI-357275;
CC Q5T681; Q13114: TRAF3; NbExp=3; IntAct=EBI-744052, EBI-357631;
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DR EMBL; AL355315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC037252; AAH37252.1; -; mRNA.
DR CCDS; CCDS31261.1; -.
DR RefSeq; NP_001009997.2; NM_001009997.2.
DR AlphaFoldDB; Q5T681; -.
DR SMR; Q5T681; -.
DR BioGRID; 135946; 13.
DR IntAct; Q5T681; 11.
DR STRING; 9606.ENSP00000359674; -.
DR iPTMnet; Q5T681; -.
DR PhosphoSitePlus; Q5T681; -.
DR BioMuta; C10orf62; -.
DR MassIVE; Q5T681; -.
DR PaxDb; Q5T681; -.
DR PeptideAtlas; Q5T681; -.
DR PRIDE; Q5T681; -.
DR ProteomicsDB; 64570; -.
DR Antibodypedia; 52145; 69 antibodies from 11 providers.
DR DNASU; 414157; -.
DR Ensembl; ENST00000370640.5; ENSP00000359674.3; ENSG00000203942.5.
DR GeneID; 414157; -.
DR KEGG; hsa:414157; -.
DR MANE-Select; ENST00000370640.5; ENSP00000359674.3; NM_001009997.3; NP_001009997.2.
DR UCSC; uc001koa.4; human.
DR CTD; 414157; -.
DR DisGeNET; 414157; -.
DR GeneCards; C10orf62; -.
DR HGNC; HGNC:23294; C10orf62.
DR HPA; ENSG00000203942; Tissue enriched (testis).
DR neXtProt; NX_Q5T681; -.
DR OpenTargets; ENSG00000203942; -.
DR PharmGKB; PA134924151; -.
DR VEuPathDB; HostDB:ENSG00000203942; -.
DR eggNOG; ENOG502SSB3; Eukaryota.
DR GeneTree; ENSGT00390000015820; -.
DR HOGENOM; CLU_079655_0_0_1; -.
DR InParanoid; Q5T681; -.
DR OMA; TIAGANH; -.
DR OrthoDB; 1346443at2759; -.
DR PhylomeDB; Q5T681; -.
DR TreeFam; TF353569; -.
DR PathwayCommons; Q5T681; -.
DR SignaLink; Q5T681; -.
DR BioGRID-ORCS; 414157; 8 hits in 1033 CRISPR screens.
DR GenomeRNAi; 414157; -.
DR Pharos; Q5T681; Tdark.
DR PRO; PR:Q5T681; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5T681; protein.
DR Bgee; ENSG00000203942; Expressed in left testis and 80 other tissues.
DR Genevisible; Q5T681; HS.
DR InterPro; IPR037649; C10orf62.
DR PANTHER; PTHR23008; PTHR23008; 1.
DR Pfam; PF17729; DUF5569; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..223
FT /note="Uncharacterized protein C10orf62"
FT /id="PRO_0000274241"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..223
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYN3"
FT VARIANT 121
FT /note="E -> D (in dbSNP:rs7093840)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030216"
SQ SEQUENCE 223 AA; 25128 MW; 85C075F7C2DDEAAE CRC64;
MLWVQRKRRR KETSECPSDK DKSPESHKAK NESWIKSHFS RLSEEKLALD NNASASGNAT
QTESGSEEVS STVHIETFTT RHGEVGSALH RESFTSRQKT SGPSVIQEIH QESGKAPSTD
EATWAAVAAC TKEIDTQGRH LAHSMLQRAI AYQHSGHLES KDINQEELRA LEEVEMKLQK
NFLTQRENTI AGANHTHTFY GHSHHSHHGH PSHQSHSLPN RRH
