CJ067_HUMAN
ID CJ067_HUMAN Reviewed; 551 AA.
AC Q8IYJ2; A8MUP9; Q5QP74; Q5SWD4;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-JUL-2016, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Uncharacterized protein C10orf67, mitochondrial {ECO:0000305};
DE Flags: Precursor;
GN Name=C10orf67 {ECO:0000312|HGNC:HGNC:28716};
GN Synonyms=LINC01552 {ECO:0000312|HGNC:HGNC:28716};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH NOD2.
RX PubMed=27812135; DOI=10.1371/journal.pone.0165420;
RA Thiebaut R., Esmiol S., Lecine P., Mahfouz B., Hermant A., Nicoletti C.,
RA Parnis S., Perroy J., Borg J.P., Pascoe L., Hugot J.P., Ollendorff V.;
RT "Characterization and Genetic Analyses of New Genes Coding for NOD2
RT Interacting Proteins.";
RL PLoS ONE 11:E0165420-E0165420(2016).
CC -!- SUBUNIT: Interacts with NOD2. {ECO:0000269|PubMed:27812135}.
CC -!- INTERACTION:
CC Q8IYJ2-2; Q96CM8: ACSF2; NbExp=3; IntAct=EBI-13381098, EBI-2876502;
CC Q8IYJ2-2; P09917: ALOX5; NbExp=3; IntAct=EBI-13381098, EBI-79934;
CC Q8IYJ2-2; Q07817: BCL2L1; NbExp=3; IntAct=EBI-13381098, EBI-78035;
CC Q8IYJ2-2; Q92843: BCL2L2; NbExp=3; IntAct=EBI-13381098, EBI-707714;
CC Q8IYJ2-2; Q8N138: ORMDL3; NbExp=3; IntAct=EBI-13381098, EBI-721750;
CC Q8IYJ2-2; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-13381098, EBI-8652744;
CC Q8IYJ2-2; Q17RD7: SYT16; NbExp=3; IntAct=EBI-13381098, EBI-10238936;
CC Q8IYJ2-2; Q6PL24: TMED8; NbExp=3; IntAct=EBI-13381098, EBI-11603430;
CC Q8IYJ2-2; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-13381098, EBI-8638294;
CC Q8IYJ2-2; Q96HH6: TMEM19; NbExp=3; IntAct=EBI-13381098, EBI-741829;
CC Q8IYJ2-2; Q9BTX3: TMEM208; NbExp=3; IntAct=EBI-13381098, EBI-12876824;
CC Q8IYJ2-2; P01375: TNF; NbExp=3; IntAct=EBI-13381098, EBI-359977;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IYJ2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IYJ2-2; Sequence=VSP_058394, VSP_058395;
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH35732.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL139281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL606469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL592296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035732; AAH35732.1; ALT_INIT; mRNA.
DR CCDS; CCDS44365.1; -. [Q8IYJ2-2]
DR RefSeq; NP_714925.2; NM_153714.2. [Q8IYJ2-2]
DR RefSeq; XP_016871518.1; XM_017016029.1.
DR AlphaFoldDB; Q8IYJ2; -.
DR SMR; Q8IYJ2; -.
DR BioGRID; 129180; 14.
DR IntAct; Q8IYJ2; 14.
DR STRING; 9606.ENSP00000321464; -.
DR GlyGen; Q8IYJ2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8IYJ2; -.
DR PhosphoSitePlus; Q8IYJ2; -.
DR BioMuta; C10orf67; -.
DR MassIVE; Q8IYJ2; -.
DR PaxDb; Q8IYJ2; -.
DR PeptideAtlas; Q8IYJ2; -.
DR PRIDE; Q8IYJ2; -.
DR ProteomicsDB; 63639; -.
DR Antibodypedia; 51754; 21 antibodies from 13 providers.
DR DNASU; 256815; -.
DR Ensembl; ENST00000673651.1; ENSP00000501139.1; ENSG00000179133.15. [Q8IYJ2-2]
DR GeneID; 256815; -.
DR KEGG; hsa:256815; -.
DR UCSC; uc010qcx.3; human. [Q8IYJ2-1]
DR CTD; 256815; -.
DR DisGeNET; 256815; -.
DR GeneCards; C10orf67; -.
DR HGNC; HGNC:28716; C10orf67.
DR HPA; ENSG00000179133; Tissue enhanced (fallopian tube, testis).
DR neXtProt; NX_Q8IYJ2; -.
DR OpenTargets; ENSG00000179133; -.
DR PharmGKB; PA134915530; -.
DR VEuPathDB; HostDB:ENSG00000179133; -.
DR eggNOG; ENOG502S05Y; Eukaryota.
DR GeneTree; ENSGT00390000003836; -.
DR HOGENOM; CLU_1478250_0_0_1; -.
DR InParanoid; Q8IYJ2; -.
DR OrthoDB; 1224715at2759; -.
DR TreeFam; TF352208; -.
DR PathwayCommons; Q8IYJ2; -.
DR SignaLink; Q8IYJ2; -.
DR BioGRID-ORCS; 256815; 9 hits in 1035 CRISPR screens.
DR ChiTaRS; C10orf67; human.
DR GenomeRNAi; 256815; -.
DR Pharos; Q8IYJ2; Tdark.
DR PRO; PR:Q8IYJ2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8IYJ2; protein.
DR Bgee; ENSG00000179133; Expressed in buccal mucosa cell and 104 other tissues.
DR ExpressionAtlas; Q8IYJ2; baseline and differential.
DR Genevisible; Q8IYJ2; HS.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR InterPro; IPR040119; C10orf67-like.
DR InterPro; IPR031651; DUF4709.
DR InterPro; IPR031711; DUF4724.
DR PANTHER; PTHR22382; PTHR22382; 1.
DR Pfam; PF15821; DUF4709; 1.
DR Pfam; PF15852; DUF4724; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..36
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 37..551
FT /note="Uncharacterized protein C10orf67, mitochondrial"
FT /evidence="ECO:0000255"
FT /id="PRO_0000089800"
FT REGION 354..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 203..315
FT /evidence="ECO:0000255"
FT COILED 405..439
FT /evidence="ECO:0000255"
FT COMPBIAS 361..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 184..185
FT /note="QF -> PL (in isoform 2)"
FT /id="VSP_058394"
FT VAR_SEQ 186..551
FT /note="Missing (in isoform 2)"
FT /id="VSP_058395"
SQ SEQUENCE 551 AA; 63656 MW; 920351A093753743 CRC64;
MMALVRDRRA HYVMSIVIRW VHCFSSSLRG TFGTRWEAMK AKATELRVCC ARRKREAREF
KPPQMRGSTR LNISDDLKIG FFSTDHATQT DSSEILSVKE LSSSTQKLAQ MMKSLQVDFG
FLKQLLQLKF EDRLKEESLS LFTILHDRIL EIEKHYQQNE DKMRKSFNQQ LADAIAVIKG
MYQQFFEVEE ENVSLQDAST VKTNILLRKL KEKEEVIKEL KEELDQYKDF GFHKMESFAK
ETSSPKSNLE KENLEYKVEN ERLLQIISEL EEEIQINLKE NSGLEDELIS MKEMAEKDHK
TIQKLMDSRD RLREELHYEK SLVQDVINKQ KEDKEMRKKY GSLSVKVARS AKGREASLSP
WPKSPPSTTA LRPHSATMSV SSAGAQKAKM PKKALKEDQA VVEDKHGLES QIEALKANLE
NEKKKVERFR KEADRLNKSW EKRFFILRNS FHVLKNEMFT RHTLFRQFAV LADTSFNYIK
VKPLLVQSRT TMTAISSSSH CTSSIDGKHV DVVSDQAALQ LSPKGKLSES PKEESLEEPS
MRQSSPAETV D
