CJ082_HUMAN
ID CJ082_HUMAN Reviewed; 234 AA.
AC Q8WW14; B3KUM9; D3DRC3; K7EKP3;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Uncharacterized protein C10orf82;
GN Name=C10orf82;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=25609838; DOI=10.1095/biolreprod.114.126250;
RA Petit F.G., Kervarrec C., Jamin S.P., Smagulova F., Hao C., Becker E.,
RA Jegou B., Chalmel F., Primig M.;
RT "Combining RNA and protein profiling data with network interactions
RT identifies genes associated with spermatogenesis in mouse and human.";
RL Biol. Reprod. 92:71-71(2015).
CC -!- INTERACTION:
CC Q8WW14-2; X5D778: ANKRD11; NbExp=3; IntAct=EBI-12831628, EBI-17183751;
CC Q8WW14-2; O75934: BCAS2; NbExp=3; IntAct=EBI-12831628, EBI-1050106;
CC Q8WW14-2; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-12831628, EBI-10242151;
CC Q8WW14-2; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-12831628, EBI-347538;
CC Q8WW14-2; Q13064: MKRN3; NbExp=3; IntAct=EBI-12831628, EBI-2340269;
CC Q8WW14-2; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-12831628, EBI-5662487;
CC Q8WW14-2; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-12831628, EBI-742688;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25609838}. Nucleus
CC {ECO:0000250|UniProtKB:Q9CQT6}. Note=Located in the cytoplasm of
CC spermatocytes and the nuclei of round spermatids and elongated
CC spermatids. {ECO:0000250|UniProtKB:Q9CQT6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8WW14-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WW14-2; Sequence=VSP_036119;
CC Name=3;
CC IsoId=Q8WW14-3; Sequence=VSP_036117, VSP_036118;
CC -!- TISSUE SPECIFICITY: Expressed in testis (at protein level). Strongly
CC expressed in peritubular cells and Leydig cells and weakly expressed in
CC the cytoplasm of spermatocytes. {ECO:0000269|PubMed:25609838}.
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DR EMBL; AK097587; BAG53491.1; -; mRNA.
DR EMBL; AC016825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW49444.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49445.1; -; Genomic_DNA.
DR EMBL; BC021737; AAH21737.1; -; mRNA.
DR CCDS; CCDS7596.1; -. [Q8WW14-2]
DR CCDS; CCDS81510.1; -. [Q8WW14-1]
DR RefSeq; NP_001317071.1; NM_001330142.1. [Q8WW14-1]
DR RefSeq; NP_653262.1; NM_144661.2. [Q8WW14-2]
DR RefSeq; XP_016871242.1; XM_017015753.1.
DR RefSeq; XP_016871244.1; XM_017015755.1.
DR AlphaFoldDB; Q8WW14; -.
DR SMR; Q8WW14; -.
DR BioGRID; 126799; 16.
DR IntAct; Q8WW14; 8.
DR STRING; 9606.ENSP00000358212; -.
DR BioMuta; C10orf82; -.
DR DMDM; 221222443; -.
DR MassIVE; Q8WW14; -.
DR PaxDb; Q8WW14; -.
DR PeptideAtlas; Q8WW14; -.
DR PRIDE; Q8WW14; -.
DR Antibodypedia; 53097; 65 antibodies from 12 providers.
DR DNASU; 143379; -.
DR Ensembl; ENST00000369210.7; ENSP00000358212.3; ENSG00000165863.17. [Q8WW14-2]
DR Ensembl; ENST00000588184.2; ENSP00000465712.1; ENSG00000165863.17. [Q8WW14-1]
DR GeneID; 143379; -.
DR KEGG; hsa:143379; -.
DR MANE-Select; ENST00000588184.2; ENSP00000465712.1; NM_001350931.2; NP_001337860.1.
DR UCSC; uc001lcr.3; human. [Q8WW14-1]
DR CTD; 143379; -.
DR DisGeNET; 143379; -.
DR GeneCards; C10orf82; -.
DR HGNC; HGNC:28500; C10orf82.
DR HPA; ENSG00000165863; Tissue enriched (testis).
DR neXtProt; NX_Q8WW14; -.
DR OpenTargets; ENSG00000165863; -.
DR PharmGKB; PA134919914; -.
DR VEuPathDB; HostDB:ENSG00000165863; -.
DR eggNOG; ENOG502SAX8; Eukaryota.
DR GeneTree; ENSGT00390000017460; -.
DR HOGENOM; CLU_143590_0_0_1; -.
DR InParanoid; Q8WW14; -.
DR OMA; VTCGCAQ; -.
DR OrthoDB; 1205710at2759; -.
DR PhylomeDB; Q8WW14; -.
DR TreeFam; TF337656; -.
DR PathwayCommons; Q8WW14; -.
DR SignaLink; Q8WW14; -.
DR BioGRID-ORCS; 143379; 12 hits in 1039 CRISPR screens.
DR GenomeRNAi; 143379; -.
DR Pharos; Q8WW14; Tdark.
DR PRO; PR:Q8WW14; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8WW14; protein.
DR Bgee; ENSG00000165863; Expressed in sperm and 109 other tissues.
DR Genevisible; Q8WW14; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR043246; C10orf82-like.
DR PANTHER; PTHR47301; PTHR47301; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..234
FT /note="Uncharacterized protein C10orf82"
FT /id="PRO_0000089807"
FT VAR_SEQ 92..110
FT /note="ECKYVKKPLQEPPIPGWAG -> GSSALKPFPLTPGHPCRFS (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036117"
FT VAR_SEQ 111..234
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036118"
FT VAR_SEQ 155..234
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_036119"
FT VARIANT 124
FT /note="T -> M (in dbSNP:rs11551267)"
FT /id="VAR_050854"
SQ SEQUENCE 234 AA; 26343 MW; B10AB6D67800822A CRC64;
MEPSKTFMRN LPITPGYSGF VPFLSCQGMS KEDDMNHCVK TFQEKTQRYK EQLRELCCAV
ATAPKLKPVN SEETVLQALH QYNLQYHPLI LECKYVKKPL QEPPIPGWAG YLPRAKVTEF
GCGTRYTVMA KNCYKDFLEI TERAKKAHLK PYEEIYGVSS TKTSAPSPKV LQHEELLPKY
PDFSIPDGSC PALGRPLRED PKTPLTCGCA QRPSIPCSGK MYLEPLSSAK YAEG
