CJ105_HUMAN
ID CJ105_HUMAN Reviewed; 133 AA.
AC Q8TEF2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Uncharacterized protein C10orf105;
GN Name=C10orf105;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK074172; BAB84998.1; -; mRNA.
DR EMBL; AL731541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC071608; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS44430.1; -.
DR RefSeq; NP_001157847.1; NM_001164375.2.
DR RefSeq; NP_001161862.1; NM_001168390.1.
DR RefSeq; XP_011538110.1; XM_011539808.2.
DR RefSeq; XP_011538111.1; XM_011539809.2.
DR AlphaFoldDB; Q8TEF2; -.
DR SMR; Q8TEF2; -.
DR STRING; 9606.ENSP00000403151; -.
DR iPTMnet; Q8TEF2; -.
DR PhosphoSitePlus; Q8TEF2; -.
DR BioMuta; C10orf105; -.
DR MassIVE; Q8TEF2; -.
DR PaxDb; Q8TEF2; -.
DR PeptideAtlas; Q8TEF2; -.
DR PRIDE; Q8TEF2; -.
DR ProteomicsDB; 74458; -.
DR DNASU; 414152; -.
DR Ensembl; ENST00000398786.2; ENSP00000381766.3; ENSG00000214688.6.
DR Ensembl; ENST00000441508.4; ENSP00000403151.2; ENSG00000214688.6.
DR GeneID; 414152; -.
DR KEGG; hsa:414152; -.
DR MANE-Select; ENST00000441508.4; ENSP00000403151.2; NM_001164375.3; NP_001157847.1.
DR UCSC; uc001jsa.2; human.
DR CTD; 414152; -.
DR DisGeNET; 414152; -.
DR GeneCards; C10orf105; -.
DR HGNC; HGNC:20304; C10orf105.
DR HPA; ENSG00000214688; Tissue enriched (brain).
DR MalaCards; C10orf105; -.
DR neXtProt; NX_Q8TEF2; -.
DR OpenTargets; ENSG00000214688; -.
DR PharmGKB; PA134923659; -.
DR VEuPathDB; HostDB:ENSG00000214688; -.
DR eggNOG; ENOG502S4ZY; Eukaryota.
DR GeneTree; ENSGT00490000043902; -.
DR HOGENOM; CLU_1849757_0_0_1; -.
DR InParanoid; Q8TEF2; -.
DR OMA; ECMPYHP; -.
DR OrthoDB; 1526580at2759; -.
DR PhylomeDB; Q8TEF2; -.
DR PathwayCommons; Q8TEF2; -.
DR SignaLink; Q8TEF2; -.
DR BioGRID-ORCS; 414152; 9 hits in 1044 CRISPR screens.
DR Pharos; Q8TEF2; Tdark.
DR PRO; PR:Q8TEF2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8TEF2; protein.
DR Bgee; ENSG00000214688; Expressed in blood and 82 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039954; DUF5527.
DR PANTHER; PTHR38325; PTHR38325; 1.
DR Pfam; PF17665; DUF5527; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..133
FT /note="Uncharacterized protein C10orf105"
FT /id="PRO_0000331530"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 105..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 54
FT /note="L -> V (in Ref. 1; BAB84998)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 133 AA; 14519 MW; 9B74E1A2A20A86AE CRC64;
MSTEGPSLAS SPAISPLAFL SAPVTPGTLA EATDPLPMLI ALACIFLLLA TCLLFMTLCK
PAALDPSRRR AHECMPHHPG SPSEPQLRLW KRLGSLRLSL HSFRHGRPTV PRQPLPGPED
NRSHCDYMES TKM
