ID   CJ120_HUMAN             Reviewed;         335 AA.
AC   Q5SQS8; B2RU17;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Uncharacterized protein C10orf120;
GN   Name=C10orf120;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-269.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-269.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q5SQS8; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12176257, EBI-16439278;
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DR   EMBL; AL731543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471066; EAW49307.1; -; Genomic_DNA.
DR   EMBL; BC140922; AAI40923.1; -; mRNA.
DR   EMBL; BC065903; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS31302.1; -.
DR   RefSeq; NP_001010912.1; NM_001010912.2.
DR   AlphaFoldDB; Q5SQS8; -.
DR   BioGRID; 134419; 4.
DR   IntAct; Q5SQS8; 2.
DR   STRING; 9606.ENSP00000331012; -.
DR   iPTMnet; Q5SQS8; -.
DR   PhosphoSitePlus; Q5SQS8; -.
DR   BioMuta; C10orf120; -.
DR   DMDM; 74743566; -.
DR   MassIVE; Q5SQS8; -.
DR   PaxDb; Q5SQS8; -.
DR   PeptideAtlas; Q5SQS8; -.
DR   PRIDE; Q5SQS8; -.
DR   Antibodypedia; 49180; 22 antibodies from 8 providers.
DR   DNASU; 399814; -.
DR   Ensembl; ENST00000329446.5; ENSP00000331012.4; ENSG00000183559.12.
DR   GeneID; 399814; -.
DR   KEGG; hsa:399814; -.
DR   MANE-Select; ENST00000329446.5; ENSP00000331012.4; NM_001010912.4; NP_001010912.1.
DR   UCSC; uc001lgn.3; human.
DR   CTD; 399814; -.
DR   GeneCards; C10orf120; -.
DR   HGNC; HGNC:25707; C10orf120.
DR   HPA; ENSG00000183559; Tissue enriched (testis).
DR   neXtProt; NX_Q5SQS8; -.
DR   OpenTargets; ENSG00000183559; -.
DR   PharmGKB; PA134871711; -.
DR   VEuPathDB; HostDB:ENSG00000183559; -.
DR   eggNOG; ENOG502RNK6; Eukaryota.
DR   GeneTree; ENSGT00390000005511; -.
DR   HOGENOM; CLU_071615_0_0_1; -.
DR   InParanoid; Q5SQS8; -.
DR   OMA; MNVVFKS; -.
DR   OrthoDB; 1334048at2759; -.
DR   PhylomeDB; Q5SQS8; -.
DR   TreeFam; TF337245; -.
DR   PathwayCommons; Q5SQS8; -.
DR   SignaLink; Q5SQS8; -.
DR   BioGRID-ORCS; 399814; 4 hits in 1035 CRISPR screens.
DR   GenomeRNAi; 399814; -.
DR   Pharos; Q5SQS8; Tdark.
DR   PRO; PR:Q5SQS8; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q5SQS8; protein.
DR   Bgee; ENSG00000183559; Expressed in left testis and 22 other tissues.
DR   ExpressionAtlas; Q5SQS8; baseline and differential.
DR   InterPro; IPR040721; DUF5520.
DR   PANTHER; PTHR47509; PTHR47509; 1.
DR   Pfam; PF17658; DUF5520; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..335
FT                   /note="Uncharacterized protein C10orf120"
FT                   /id="PRO_0000243940"
FT   REGION          201..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..236
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         20
FT                   /note="T -> K (in dbSNP:rs41448048)"
FT                   /id="VAR_050859"
FT   VARIANT         269
FT                   /note="A -> T (in dbSNP:rs2947594)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT                   /id="VAR_050860"
SQ   SEQUENCE   335 AA;  39268 MW;  5325092A9DF7A5C4 CRC64;
     MIREWKNDCQ RIEKQRASDT MVQERKNEKP VRIFNTNSSF QDQAPTCCQE DLSSASPLRI
     WSKFYRSDPR IALGKYSPLE KEILRLGGIH TIAARRLLAY KQEEECRMLK ELQLLSPDYK
     QAMEYKKKHS SPCAICVPLE KIWTAKVIAP LEAFKMPQRE QVNVSKHIER MRLARALGNH
     QPLPYIERFT RSSFLSGVGL GPMAKNKARR KEDNYDTHNC DDANQDKKEE AEGKNTKRRE
     IKMNVVFKSK EPKKCLTYHG NDRKSFLPAK KPERSIAGLT NRNLFCISEF PGDLMLMNQD
     FISRRDHFSD LVKTYSLEEE SIWKERMRKA TPYHY