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CJE1_CONFR
ID   CJE1_CONFR              Reviewed;          76 AA.
AC   Q0N4U4;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Alpha/kappa-conotoxin-like fe14.1;
DE   Flags: Precursor;
OS   Conus ferrugineus (Cone snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX   NCBI_TaxID=379542;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16819832; DOI=10.1021/bi060263r;
RA   Imperial J.S., Bansal P.S., Alewood P.F., Daly N.L., Craik D.J.,
RA   Sporning A., Terlau H., Lopez-Vera E., Bandyopadhyay P.K., Olivera B.M.;
RT   "A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a
RT   new superfamily of conotoxins.";
RL   Biochemistry 45:8331-8340(2006).
CC   -!- FUNCTION: Highly inhibits both nicotinic acetylcholine receptors
CC       (neuronal (alpha-3/beta-4) and neuromuscular (alpha-1/beta-
CC       1/epsilon/delta) subtypes) and the voltage-gated potassium channel
CC       Kv1.6/KCNA6 subtype. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin J superfamily. {ECO:0000305}.
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DR   EMBL; DQ447644; ABE27010.1; -; mRNA.
DR   AlphaFoldDB; Q0N4U4; -.
DR   SMR; Q0N4U4; -.
DR   TCDB; 8.B.38.1.2; the conotoxin j (ctx j) family.
DR   ConoServer; 1186; Fe14.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Acetylcholine receptor inhibiting toxin; Amidation; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..39
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000260018"
FT   PEPTIDE         40..64
FT                   /note="Alpha/kappa-conotoxin-like fe14.1"
FT                   /id="PRO_0000260019"
FT   PROPEP          65..76
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000260020"
FT   MOD_RES         64
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..63
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   76 AA;  8108 MW;  4BCDAB0D64EBB0E7 CRC64;
     MPSVRSVTCC CLLWMMLSVQ LVTPGSPGTA QLSGHRTARS PGSTICKMAC RTGNGHKYPF
     CNCRGKRDVV SSSMAV
 
 
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