ID   CJE28_CONBU             Reviewed;          76 AA.
AC   P0CY83;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Conotoxin Bu28;
DE   Flags: Precursor;
OS   Conus bullatus (Bubble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Textilia.
OX   NCBI_TaxID=89438;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21266071; DOI=10.1186/1471-2164-12-60;
RA   Hu H., Bandyopadhyay P.K., Olivera B.M., Yandell M.;
RT   "Characterization of the Conus bullatus genome and its venom-duct
RT   transcriptome.";
RL   BMC Genomics 12:60-60(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin J superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CY83; -.
DR   TCDB; 8.B.38.1.1; the conotoxin j (ctx j) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..39
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000409982"
FT   PEPTIDE         40..69
FT                   /note="Conotoxin Bu28"
FT                   /id="PRO_0000409983"
FT   PROPEP          71..76
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000409984"
FT   MOD_RES         69
FT                   /note="Arginine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..65
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   76 AA;  8022 MW;  670624680CBBB7D6 CRC64;
     MTSVQSATCC CLLWLVLCVQ LVTPDSPATA QLSRHLTARV PVGPALAYAC SVMCAKGYDT
     VVCTCTRRRG VVSSSI