CJE2_CONFR
ID CJE2_CONFR Reviewed; 76 AA.
AC Q0N4U3;
DT 14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 39.
DE RecName: Full=Alpha/kappa-conotoxin-like fe14.2;
DE Flags: Precursor;
OS Conus ferrugineus (Cone snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX NCBI_TaxID=379542;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=16819832; DOI=10.1021/bi060263r;
RA Imperial J.S., Bansal P.S., Alewood P.F., Daly N.L., Craik D.J.,
RA Sporning A., Terlau H., Lopez-Vera E., Bandyopadhyay P.K., Olivera B.M.;
RT "A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a
RT new superfamily of conotoxins.";
RL Biochemistry 45:8331-8340(2006).
CC -!- FUNCTION: Highly inhibits both nicotinic acetylcholine receptors
CC (neuronal (alpha-3/beta-4) and neuromuscular (alpha-1/beta-
CC 1/epsilon/delta) subtypes) and the voltage-gated potassium channel
CC Kv1.6/KCNA6 subtype. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The cysteine framework is XIV (C-C-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin J superfamily. {ECO:0000305}.
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DR EMBL; DQ447645; ABE27011.1; -; mRNA.
DR AlphaFoldDB; Q0N4U3; -.
DR SMR; Q0N4U3; -.
DR ConoServer; 1187; Fe14.2 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Acetylcholine receptor inhibiting toxin; Amidation; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin;
KW Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW Voltage-gated potassium channel impairing toxin.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT PROPEP 25..39
FT /evidence="ECO:0000250"
FT /id="PRO_0000260021"
FT PEPTIDE 40..64
FT /note="Alpha/kappa-conotoxin-like fe14.2"
FT /id="PRO_0000260022"
FT PROPEP 65..76
FT /evidence="ECO:0000250"
FT /id="PRO_0000260023"
FT MOD_RES 64
FT /note="Arginine amide"
FT /evidence="ECO:0000250"
FT DISULFID 46..61
FT /evidence="ECO:0000250"
FT DISULFID 50..63
FT /evidence="ECO:0000250"
SQ SEQUENCE 76 AA; 8064 MW; A668DC3AB4587323 CRC64;
MPSVRSVTCC CLLWMMLSVQ LVTPGSPGTA QLSGQRTARS SGSTVCKMMC RLGYGHLYPS
CGCRGKRDVV SSSMAV
