ID   CJTL7_EPIJA             Reviewed;          53 AA.
AC   P0DPE7;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   28-FEB-2018, sequence version 1.
DT   25-MAY-2022, entry version 5.
DE   RecName: Full=Toxin CjTL7 {ECO:0000303|PubMed:29109403};
DE   Flags: Precursor;
OS   Epiactis japonica (Sea anemone) (Cnidopus japonicus).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Epiactis.
OX   NCBI_TaxID=58804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND BIOASSAY.
RX   PubMed=29109403; DOI=10.1038/s41598-017-14961-1;
RA   Babenko V.V., Mikov A.N., Manuvera V.A., Anikanov N.A., Kovalchuk S.I.,
RA   Andreev Y.A., Logashina Y.A., Kornilov D.A., Manolov A.I., Sanamyan N.P.,
RA   Sanamyan K.E., Kostryukova E.S., Kozlov S.A., Grishin E.V., Govorun V.M.,
RA   Lazarev V.N.;
RT   "Identification of unusual peptides with new Cys frameworks in the venom of
RT   the cold-water sea anemone Cnidopus japonicus.";
RL   Sci. Rep. 7:14534-14534(2017).
CC   -!- FUNCTION: In vivo, only causes a weak change in behavior in shrimps
CC       (C.multidentata) (slight twitching of the walking legs), but no lethal
CC       effect is observed. No activity is observed when injected into fly
CC       larvae (M.domestica). {ECO:0000269|PubMed:29109403}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29109403}.
CC       Nematocyst {ECO:0000305}.
CC   -!- PTM: Contains 4 disulfide bonds. {ECO:0000305}.
CC   -!- CAUTION: Toxicity tests have been done on recombinant non-amidated
CC       toxin. The sequence shown in supplementary table 3 is longer than the
CC       sequence shown here. {ECO:0000305|PubMed:29109403}.
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DR   AlphaFoldDB; P0DPE7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Amidation; Disulfide bond; Nematocyst; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..51
FT                   /note="Toxin CjTL7"
FT                   /id="PRO_0000443397"
FT   MOD_RES         51
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   53 AA;  5650 MW;  F53C5CB2908BB3EC CRC64;
     MMIKVLLLLS SALVLFTPEA EGGCGCHTEC SLQCSFSGCG YVCGLRCRCS WGK