CK001_HUMAN
ID CK001_HUMAN Reviewed; 150 AA.
AC Q9H5F2; Q6I9X7; Q9NQC6;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=UPF0686 protein C11orf1;
GN Name=C11orf1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND VARIANT ALA-40.
RX PubMed=10873569; DOI=10.1006/bbrc.2000.2910;
RA O'Brien K.P., Tapia-Paez I., Staahle-Baeckdahl M., Kedra D., Dumanski J.P.;
RT "Characterization of five novel human genes in the 11q13-q22 region.";
RL Biochem. Biophys. Res. Commun. 273:90-94(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-40.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic testis carcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9H5F2; P21549: AGXT; NbExp=3; IntAct=EBI-718615, EBI-727098;
CC Q9H5F2; X5D778: ANKRD11; NbExp=3; IntAct=EBI-718615, EBI-17183751;
CC Q9H5F2; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-718615, EBI-742909;
CC Q9H5F2; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-718615, EBI-12006308;
CC Q9H5F2; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-718615, EBI-1166928;
CC Q9H5F2; Q8WUW1: BRK1; NbExp=3; IntAct=EBI-718615, EBI-2837444;
CC Q9H5F2; Q8NEC5: CATSPER1; NbExp=5; IntAct=EBI-718615, EBI-744545;
CC Q9H5F2; Q9NZN8: CNOT2; NbExp=3; IntAct=EBI-718615, EBI-743033;
CC Q9H5F2; P27658: COL8A1; NbExp=3; IntAct=EBI-718615, EBI-747133;
CC Q9H5F2; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-718615, EBI-9679045;
CC Q9H5F2; Q86UW9: DTX2; NbExp=3; IntAct=EBI-718615, EBI-740376;
CC Q9H5F2; O75593: FOXH1; NbExp=3; IntAct=EBI-718615, EBI-1759806;
CC Q9H5F2; O43559: FRS3; NbExp=3; IntAct=EBI-718615, EBI-725515;
CC Q9H5F2; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-718615, EBI-14103818;
CC Q9H5F2; O14964: HGS; NbExp=3; IntAct=EBI-718615, EBI-740220;
CC Q9H5F2; P49639: HOXA1; NbExp=3; IntAct=EBI-718615, EBI-740785;
CC Q9H5F2; P31273: HOXC8; NbExp=3; IntAct=EBI-718615, EBI-1752118;
CC Q9H5F2; O43593: HR; NbExp=3; IntAct=EBI-718615, EBI-2880706;
CC Q9H5F2; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-718615, EBI-2556193;
CC Q9H5F2; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-718615, EBI-6426443;
CC Q9H5F2; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-718615, EBI-11953846;
CC Q9H5F2; P32242: OTX1; NbExp=3; IntAct=EBI-718615, EBI-740446;
CC Q9H5F2; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-718615, EBI-11022007;
CC Q9H5F2; Q9UBV8: PEF1; NbExp=3; IntAct=EBI-718615, EBI-724639;
CC Q9H5F2; P78337: PITX1; NbExp=5; IntAct=EBI-718615, EBI-748265;
CC Q9H5F2; Q9NRQ2: PLSCR4; NbExp=5; IntAct=EBI-718615, EBI-769257;
CC Q9H5F2; O43741: PRKAB2; NbExp=3; IntAct=EBI-718615, EBI-1053424;
CC Q9H5F2; O75360: PROP1; NbExp=5; IntAct=EBI-718615, EBI-9027467;
CC Q9H5F2; P0CG20: PRR35; NbExp=3; IntAct=EBI-718615, EBI-11986293;
CC Q9H5F2; Q8NB12: SMYD1; NbExp=3; IntAct=EBI-718615, EBI-8463848;
CC Q9H5F2; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-718615, EBI-750487;
CC Q9H5F2; Q08117-2: TLE5; NbExp=3; IntAct=EBI-718615, EBI-11741437;
CC Q9H5F2; O43711: TLX3; NbExp=3; IntAct=EBI-718615, EBI-3939165;
CC Q9H5F2; Q15915: ZIC1; NbExp=3; IntAct=EBI-718615, EBI-11963196;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10873569}.
CC -!- SIMILARITY: Belongs to the UPF0686 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ250229; CAB96538.1; -; mRNA.
DR EMBL; AK027152; BAB15674.1; -; mRNA.
DR EMBL; CR457378; CAG33659.1; -; mRNA.
DR EMBL; BC020628; AAH20628.1; -; mRNA.
DR CCDS; CCDS8350.1; -.
DR RefSeq; NP_001317300.1; NM_001330371.1.
DR RefSeq; NP_073598.1; NM_022761.2.
DR AlphaFoldDB; Q9H5F2; -.
DR BioGRID; 122286; 42.
DR IntAct; Q9H5F2; 35.
DR STRING; 9606.ENSP00000260276; -.
DR iPTMnet; Q9H5F2; -.
DR PhosphoSitePlus; Q9H5F2; -.
DR BioMuta; C11orf1; -.
DR DMDM; 47605552; -.
DR MassIVE; Q9H5F2; -.
DR PaxDb; Q9H5F2; -.
DR PeptideAtlas; Q9H5F2; -.
DR PRIDE; Q9H5F2; -.
DR ProteomicsDB; 80904; -.
DR Antibodypedia; 51443; 89 antibodies from 15 providers.
DR DNASU; 64776; -.
DR Ensembl; ENST00000260276.8; ENSP00000260276.3; ENSG00000137720.8.
DR GeneID; 64776; -.
DR KEGG; hsa:64776; -.
DR MANE-Select; ENST00000260276.8; ENSP00000260276.3; NM_022761.3; NP_073598.1.
DR UCSC; uc001pmd.4; human.
DR CTD; 64776; -.
DR GeneCards; C11orf1; -.
DR HGNC; HGNC:1163; C11orf1.
DR HPA; ENSG00000137720; Low tissue specificity.
DR neXtProt; NX_Q9H5F2; -.
DR OpenTargets; ENSG00000137720; -.
DR PharmGKB; PA25477; -.
DR VEuPathDB; HostDB:ENSG00000137720; -.
DR eggNOG; ENOG502S5NG; Eukaryota.
DR GeneTree; ENSGT00390000002905; -.
DR InParanoid; Q9H5F2; -.
DR OMA; WNEERYD; -.
DR OrthoDB; 1331053at2759; -.
DR PhylomeDB; Q9H5F2; -.
DR TreeFam; TF329225; -.
DR PathwayCommons; Q9H5F2; -.
DR SignaLink; Q9H5F2; -.
DR BioGRID-ORCS; 64776; 6 hits in 1049 CRISPR screens.
DR ChiTaRS; C11orf1; human.
DR GeneWiki; C11orf1; -.
DR GenomeRNAi; 64776; -.
DR Pharos; Q9H5F2; Tdark.
DR PRO; PR:Q9H5F2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H5F2; protein.
DR Bgee; ENSG00000137720; Expressed in sperm and 177 other tissues.
DR ExpressionAtlas; Q9H5F2; baseline and differential.
DR Genevisible; Q9H5F2; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009524; DUF1143.
DR PANTHER; PTHR34524:SF1; PTHR34524:SF1; 1.
DR Pfam; PF06608; DUF1143; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..150
FT /note="UPF0686 protein C11orf1"
FT /id="PRO_0000089829"
FT VARIANT 40
FT /note="V -> A (in dbSNP:rs9280)"
FT /evidence="ECO:0000269|PubMed:10873569, ECO:0000269|Ref.3"
FT /id="VAR_054163"
FT VARIANT 49
FT /note="K -> Q (in dbSNP:rs11540721)"
FT /id="VAR_050861"
FT VARIANT 85
FT /note="Q -> H (in dbSNP:rs3180820)"
FT /id="VAR_050862"
SQ SEQUENCE 150 AA; 17785 MW; BB1D0B7EDE8F2C7B CRC64;
MAASQCLCCS KFLFQRQNLA CFLTNPHCGS LVNADGHGEV WTDWNNMSKF FQYGWRCTTN
ENTYSNRTLM GNWNQERYDL RNIVQPKPLP SQFGHYFETT YDTSYNNKMP LSTHRFKREP
HWFPGHQPEL DPPRYKCTEK STYMNSYSKP
