CK001_MOUSE
ID CK001_MOUSE Reviewed; 166 AA.
AC Q9D131; Q3TM17; Q3TYP3; Q4FK47; Q8K0A6; Q9D589; Q9JHT0;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=UPF0686 protein C11orf1 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10873569; DOI=10.1006/bbrc.2000.2910;
RA O'Brien K.P., Tapia-Paez I., Staahle-Baeckdahl M., Kedra D., Dumanski J.P.;
RT "Characterization of five novel human genes in the 11q13-q22 region.";
RL Biochem. Biophys. Res. Commun. 273:90-94(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP GLN-GLY-PRO-GLY-ILE-166 INS.
RC STRAIN=C57BL/6J;
RC TISSUE=Brain cortex, Embryo, Inner ear, Mammary gland, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J.,
RA Wiemann S., Schick M., Korn B.;
RT "Cloning of mouse full open reading frames in Gateway(R) system entry
RT vector (pDONR201).";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP GLN-GLY-PRO-GLY-ILE-166 INS.
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D131-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D131-2; Sequence=VSP_027584;
CC -!- SIMILARITY: Belongs to the UPF0686 family. {ECO:0000305}.
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DR EMBL; AJ250230; CAB96546.1; -; mRNA.
DR EMBL; AK004016; BAB23127.1; -; mRNA.
DR EMBL; AK015671; BAB29923.1; -; mRNA.
DR EMBL; AK043513; BAC31564.1; -; mRNA.
DR EMBL; AK158460; BAE34519.1; -; mRNA.
DR EMBL; AK166202; BAE38625.1; -; mRNA.
DR EMBL; CT010205; CAJ18413.1; -; mRNA.
DR EMBL; BC032012; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS23173.1; -. [Q9D131-1]
DR CCDS; CCDS80996.1; -. [Q9D131-2]
DR RefSeq; NP_001298002.1; NM_001311073.1. [Q9D131-2]
DR RefSeq; NP_075972.2; NM_023483.3. [Q9D131-1]
DR AlphaFoldDB; Q9D131; -.
DR STRING; 10090.ENSMUSP00000041803; -.
DR iPTMnet; Q9D131; -.
DR PhosphoSitePlus; Q9D131; -.
DR PaxDb; Q9D131; -.
DR PRIDE; Q9D131; -.
DR Antibodypedia; 51443; 89 antibodies from 15 providers.
DR DNASU; 68721; -.
DR Ensembl; ENSMUST00000042468; ENSMUSP00000041803; ENSMUSG00000037971. [Q9D131-1]
DR Ensembl; ENSMUST00000042576; ENSMUSP00000046890; ENSMUSG00000037971. [Q9D131-2]
DR GeneID; 68721; -.
DR KEGG; mmu:68721; -.
DR UCSC; uc009pko.1; mouse. [Q9D131-2]
DR UCSC; uc009pkp.1; mouse. [Q9D131-1]
DR MGI; MGI:1915971; 1110032A03Rik.
DR VEuPathDB; HostDB:ENSMUSG00000037971; -.
DR eggNOG; ENOG502S5NG; Eukaryota.
DR GeneTree; ENSGT00390000002905; -.
DR HOGENOM; CLU_117702_0_0_1; -.
DR InParanoid; Q9D131; -.
DR OMA; WNEERYD; -.
DR OrthoDB; 1331053at2759; -.
DR PhylomeDB; Q9D131; -.
DR TreeFam; TF329225; -.
DR BioGRID-ORCS; 68721; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q9D131; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9D131; protein.
DR Bgee; ENSMUSG00000037971; Expressed in skin of snout and 257 other tissues.
DR ExpressionAtlas; Q9D131; baseline and differential.
DR Genevisible; Q9D131; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR009524; DUF1143.
DR PANTHER; PTHR34524:SF1; PTHR34524:SF1; 1.
DR Pfam; PF06608; DUF1143; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..166
FT /note="UPF0686 protein C11orf1 homolog"
FT /id="PRO_0000089830"
FT VAR_SEQ 1..13
FT /note="MAVSCSLNHSTYL -> MELPYRNRFYSLRCSSKSLYSPSSYTSII (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027584"
FT VARIANT 166
FT /note="S -> SQGPGI"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:16141072"
FT CONFLICT 8
FT /note="N -> S (in Ref. 1; CAB96546 and 2; BAE34519)"
FT /evidence="ECO:0000305"
FT CONFLICT 14
FT /note="Q -> K (in Ref. 1; CAB96546 and 2; BAE34519)"
FT /evidence="ECO:0000305"
FT CONFLICT 158
FT /note="V -> I (in Ref. 4; BC032012)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 166 AA; 19527 MW; B299BEE9DB28E0EC CRC64;
MAVSCSLNHS TYLQRQNLVC YLRNPHYGSL IYADGHGEVW TDWNDMSKFL QYGWRCTTNE
NSYSNRTLVG NWNQERYDLK NIVKPKPLPS QFGHAFETTY DANYSRKKPQ STHRFKREPH
WFPGHQPELD PPHYKCTAKS TYMTNYSEPQ PTHYSCCVYD PSVSQS
