CK016_HUMAN
ID CK016_HUMAN Reviewed; 467 AA.
AC Q9NQ32; Q53FB2; Q8N6Y9;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Uncharacterized protein C11orf16;
GN Name=C11orf16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RX PubMed=11528127; DOI=10.1159/000056999;
RA Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A.,
RA Zabel B., Hankeln T., Schmidt E.R.;
RT "Comparative genomic sequencing reveals a strikingly similar architecture
RT of a conserved syntenic region on human chromosome 11p15.3 (including gene
RT ST5) and mouse chromosome 7.";
RL Cytogenet. Cell Genet. 93:284-290(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-210.
RC TISSUE=Lung;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NQ32-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NQ32-2; Sequence=VSP_039850;
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DR EMBL; AJ400877; CAB92289.1; -; Genomic_DNA.
DR EMBL; AK223377; BAD97097.1; -; mRNA.
DR EMBL; AC026894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027865; AAH27865.1; -; mRNA.
DR CCDS; CCDS7794.1; -. [Q9NQ32-1]
DR RefSeq; NP_065694.2; NM_020643.2. [Q9NQ32-1]
DR RefSeq; XP_016873502.1; XM_017018013.1. [Q9NQ32-1]
DR AlphaFoldDB; Q9NQ32; -.
DR BioGRID; 121181; 14.
DR IntAct; Q9NQ32; 2.
DR MINT; Q9NQ32; -.
DR STRING; 9606.ENSP00000318999; -.
DR PhosphoSitePlus; Q9NQ32; -.
DR BioMuta; C11orf16; -.
DR DMDM; 308153616; -.
DR jPOST; Q9NQ32; -.
DR MassIVE; Q9NQ32; -.
DR PaxDb; Q9NQ32; -.
DR PeptideAtlas; Q9NQ32; -.
DR PRIDE; Q9NQ32; -.
DR ProteomicsDB; 82066; -. [Q9NQ32-1]
DR ProteomicsDB; 82067; -. [Q9NQ32-2]
DR Antibodypedia; 55579; 53 antibodies from 10 providers.
DR DNASU; 56673; -.
DR Ensembl; ENST00000326053.10; ENSP00000318999.5; ENSG00000176029.14. [Q9NQ32-1]
DR Ensembl; ENST00000525780.5; ENSP00000436818.1; ENSG00000176029.14. [Q9NQ32-2]
DR GeneID; 56673; -.
DR KEGG; hsa:56673; -.
DR MANE-Select; ENST00000326053.10; ENSP00000318999.5; NM_020643.3; NP_065694.2.
DR UCSC; uc001mhb.5; human. [Q9NQ32-1]
DR CTD; 56673; -.
DR GeneCards; C11orf16; -.
DR HGNC; HGNC:1169; C11orf16.
DR HPA; ENSG00000176029; Tissue enhanced (choroid plexus, fallopian tube, lymphoid tissue).
DR neXtProt; NX_Q9NQ32; -.
DR OpenTargets; ENSG00000176029; -.
DR VEuPathDB; HostDB:ENSG00000176029; -.
DR eggNOG; ENOG502RXS8; Eukaryota.
DR GeneTree; ENSGT00390000012348; -.
DR HOGENOM; CLU_056300_0_0_1; -.
DR InParanoid; Q9NQ32; -.
DR OMA; FTCPFAL; -.
DR OrthoDB; 1189809at2759; -.
DR PhylomeDB; Q9NQ32; -.
DR TreeFam; TF336135; -.
DR PathwayCommons; Q9NQ32; -.
DR SignaLink; Q9NQ32; -.
DR BioGRID-ORCS; 56673; 5 hits in 1035 CRISPR screens.
DR ChiTaRS; C11orf16; human.
DR GeneWiki; C11orf16; -.
DR GenomeRNAi; 56673; -.
DR Pharos; Q9NQ32; Tdark.
DR PRO; PR:Q9NQ32; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9NQ32; protein.
DR Bgee; ENSG00000176029; Expressed in epithelium of bronchus and 131 other tissues.
DR ExpressionAtlas; Q9NQ32; baseline and differential.
DR Genevisible; Q9NQ32; HS.
DR InterPro; IPR032770; DUF4537.
DR Pfam; PF15057; DUF4537; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..467
FT /note="Uncharacterized protein C11orf16"
FT /id="PRO_0000089832"
FT REGION 416..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 403..467
FT /note="TRYSNICKEEKDHKQQRAQTAVVGTTKELVSKATHMKPPRTPPGEAEHRKRS
FT QSLAICQWNKNSR -> KE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039850"
FT VARIANT 144
FT /note="P -> L (in dbSNP:rs2568076)"
FT /id="VAR_056827"
FT VARIANT 210
FT /note="V -> L (in dbSNP:rs11042127)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_056828"
FT CONFLICT 169
FT /note="Q -> R (in Ref. 2; BAD97097)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="P -> A (in Ref. 2; BAD97097 and 4; AAH27865)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="L -> P (in Ref. 1; CAB92289, 2; BAD97097 and 4;
FT AAH27865)"
FT /evidence="ECO:0000305"
FT CONFLICT 423
FT /note="A -> V (in Ref. 1; CAB92289 and 2; BAD97097)"
FT /evidence="ECO:0000305"
FT CONFLICT 442
FT /note="R -> Q (in Ref. 1; CAB92289)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 467 AA; 51609 MW; 10FB8E35E60D2298 CRC64;
MESSTGPRMP LLKYCSVATS LKAPGWDGAA PPWDLSFTYP FALQAPWLTG HKPLARHASS
CPCLHVADPA WQGPGWLGRA GDAANTWVLA RREADGFYYR AQIKATPELE RQGVLLVEFE
APLVAGPKLP AQQQRVVLEE DVIPLSPSVG YSLRPGDKVL ALWEPGQQQY GPGTVLLGLE
MRDPQRASKE KEITVHFWNG KAAKVPLGGV QSVSLTIWKK AVERLHKSFT REHPRPLHWA
PCCSLLGPIT GRITNELPPD APFLCPLCHH HACCQLLCQG CLCGCPPCGT TWWPLTRTSE
VMARELPELE PTAQLLPLEG PKEEKVAMHA PLAVSSSSSS SCEQDGVEND LEMGPPQRLM
VNSAVNTDPI FLEMPLRQSG LCQPEWRYWK RNGPEPCLGK PGTRYSNICK EEKDHKQQRA
QTAVVGTTKE LVSKATHMKP PRTPPGEAEH RKRSQSLAIC QWNKNSR
