ID   CK021_HUMAN             Reviewed;         132 AA.
AC   Q9P2W6;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Uncharacterized protein C11orf21;
GN   Name=C11orf21;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11054561; DOI=10.1016/s0378-1119(00)00377-2;
RA   Zhu X., Higashimoto K., Soejima H., Yatsuki H., Sugihara H., Mukai T.,
RA   Joh K.;
RT   "C11orf21, a novel gene within the Beckwith-Wiedemann syndrome region in
RT   human chromosome 11p15.5.";
RL   Gene 256:311-317(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in heart.
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DR   EMBL; AB029488; BAA89482.1; -; mRNA.
DR   EMBL; AC129929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS86168.1; -.
DR   RefSeq; NP_001136418.1; NM_001142946.2.
DR   RefSeq; NP_001316887.1; NM_001329958.1.
DR   AlphaFoldDB; Q9P2W6; -.
DR   STRING; 9606.ENSP00000406541; -.
DR   BioMuta; C11orf21; -.
DR   PaxDb; Q9P2W6; -.
DR   PRIDE; Q9P2W6; -.
DR   Antibodypedia; 51578; 40 antibodies from 8 providers.
DR   DNASU; 29125; -.
DR   Ensembl; ENST00000381153.8; ENSP00000370545.4; ENSG00000110665.12.
DR   GeneID; 29125; -.
DR   KEGG; hsa:29125; -.
DR   MANE-Select; ENST00000381153.8; ENSP00000370545.4; NM_001329958.2; NP_001316887.1.
DR   UCSC; uc001lvv.3; human.
DR   CTD; 29125; -.
DR   DisGeNET; 29125; -.
DR   GeneCards; C11orf21; -.
DR   HGNC; HGNC:13231; C11orf21.
DR   HPA; ENSG00000110665; Group enriched (bone marrow, heart muscle, lymphoid tissue).
DR   MIM; 611033; gene.
DR   neXtProt; NX_Q9P2W6; -.
DR   OpenTargets; ENSG00000110665; -.
DR   PharmGKB; PA25486; -.
DR   VEuPathDB; HostDB:ENSG00000110665; -.
DR   eggNOG; ENOG502TERA; Eukaryota.
DR   GeneTree; ENSGT00390000000843; -.
DR   InParanoid; Q9P2W6; -.
DR   OMA; RAGCGMQ; -.
DR   OrthoDB; 1395020at2759; -.
DR   PathwayCommons; Q9P2W6; -.
DR   SignaLink; Q9P2W6; -.
DR   BioGRID-ORCS; 29125; 11 hits in 1018 CRISPR screens.
DR   GenomeRNAi; 29125; -.
DR   Pharos; Q9P2W6; Tdark.
DR   PRO; PR:Q9P2W6; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9P2W6; protein.
DR   Bgee; ENSG00000110665; Expressed in granulocyte and 115 other tissues.
DR   ExpressionAtlas; Q9P2W6; baseline and differential.
DR   Genevisible; Q9P2W6; HS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027894; DUF4620.
DR   Pfam; PF15399; DUF4620; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..132
FT                   /note="Uncharacterized protein C11orf21"
FT                   /id="PRO_0000089834"
FT   REGION          17..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   132 AA;  14447 MW;  3D8A2246EC0A7683 CRC64;
     MGRTWCGMWR RRRPGRRSAV PRWPHLSSQS GVEPPDRWTG TPGWPSRDQE APGSMMPPAA
     AQPSAHGALV PPATAHEPVD HPALHWLACC CCLSLPGQLP LAIRLGWDLD LEAGPSSGKL
     CPRARRWQPL PS