CK024_HUMAN
ID CK024_HUMAN Reviewed; 449 AA.
AC Q96F05; Q9H2K4;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Uncharacterized protein C11orf24;
DE AltName: Full=Protein DM4E3;
DE Flags: Precursor;
GN Name=C11orf24; ORFNames=FP2568, UNQ1872/PRO4315;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11401438; DOI=10.1006/geno.2000.6492;
RA Twells R.C.J., Metzker M.L., Brown S.D., Cox R., Garey C., Hammond H.,
RA Hey P.J., Levy E., Nakagawa Y., Philips M.S., Todd J.A., Hess J.F.;
RT "The sequence and gene characterization of a 400-kb candidate region for
RT IDDM4 on chromosome 11q13.";
RL Genomics 72:231-242(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-97.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-97.
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-97.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=24312644; DOI=10.1371/journal.pone.0082223;
RA Fraisier V., Kasri A., Miserey-Lenkei S., Sibarita J.B., Nair D.,
RA Mayeux A., Bardin S., Toyoda Y., Poser I., Poznyakovskiy A., Goud B.,
RA Hyman A.A., Dimitrov A.;
RT "C11ORF24 is a novel type I membrane protein that cycles between the Golgi
RT apparatus and the plasma membrane in Rab6-positive vesicles.";
RL PLoS ONE 8:E82223-E82223(2013).
CC -!- INTERACTION:
CC Q96F05; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-2836238, EBI-6942903;
CC Q96F05; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-2836238, EBI-18304435;
CC Q96F05; O15552: FFAR2; NbExp=3; IntAct=EBI-2836238, EBI-2833872;
CC Q96F05; O14880: MGST3; NbExp=3; IntAct=EBI-2836238, EBI-724754;
CC Q96F05; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-2836238, EBI-18159983;
CC Q96F05; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-2836238, EBI-17280858;
CC Q96F05; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-2836238, EBI-11742770;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24312644};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:24312644}.
CC Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000269|PubMed:24312644}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:24312644}. Note=Cycles to the plasma membrane via
CC endosomes in a pH sensitive manner. Associated with Rab6-positive
CC vesicles.
CC -!- TISSUE SPECIFICITY: Highest expression in heart, placenta, liver,
CC pancreas and colon. Also detected in brain, lung, skeletal muscle,
CC kidney, spleen, prostate, testis, ovary and small intestine. Lowest
CC expression in thymus and leukocytes. {ECO:0000269|PubMed:11401438}.
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DR EMBL; AF264781; AAG36936.1; -; mRNA.
DR EMBL; AY358754; AAQ89114.1; -; mRNA.
DR EMBL; AF370372; AAQ15208.1; -; mRNA.
DR EMBL; BC011765; AAH11765.1; -; mRNA.
DR CCDS; CCDS8180.1; -.
DR RefSeq; NP_001287842.1; NM_001300913.1.
DR RefSeq; NP_071733.1; NM_022338.3.
DR RefSeq; XP_005274110.1; XM_005274053.3.
DR AlphaFoldDB; Q96F05; -.
DR BioGRID; 119808; 18.
DR IntAct; Q96F05; 15.
DR STRING; 9606.ENSP00000307264; -.
DR GlyGen; Q96F05; 3 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q96F05; -.
DR PhosphoSitePlus; Q96F05; -.
DR BioMuta; C11orf24; -.
DR DMDM; 143811376; -.
DR MassIVE; Q96F05; -.
DR MaxQB; Q96F05; -.
DR PaxDb; Q96F05; -.
DR PeptideAtlas; Q96F05; -.
DR PRIDE; Q96F05; -.
DR ProteomicsDB; 76480; -.
DR Antibodypedia; 2629; 71 antibodies from 17 providers.
DR DNASU; 53838; -.
DR Ensembl; ENST00000304271.11; ENSP00000307264.6; ENSG00000171067.11.
DR GeneID; 53838; -.
DR KEGG; hsa:53838; -.
DR MANE-Select; ENST00000304271.11; ENSP00000307264.6; NM_022338.4; NP_071733.1.
DR UCSC; uc001onr.5; human.
DR CTD; 53838; -.
DR DisGeNET; 53838; -.
DR GeneCards; C11orf24; -.
DR HGNC; HGNC:1174; C11orf24.
DR HPA; ENSG00000171067; Low tissue specificity.
DR MIM; 610880; gene.
DR neXtProt; NX_Q96F05; -.
DR OpenTargets; ENSG00000171067; -.
DR PharmGKB; PA25488; -.
DR VEuPathDB; HostDB:ENSG00000171067; -.
DR eggNOG; ENOG502RZBP; Eukaryota.
DR GeneTree; ENSGT00940000153377; -.
DR HOGENOM; CLU_056955_0_0_1; -.
DR InParanoid; Q96F05; -.
DR OMA; KMPATDS; -.
DR OrthoDB; 1528686at2759; -.
DR PhylomeDB; Q96F05; -.
DR TreeFam; TF336966; -.
DR PathwayCommons; Q96F05; -.
DR SignaLink; Q96F05; -.
DR BioGRID-ORCS; 53838; 10 hits in 1067 CRISPR screens.
DR ChiTaRS; C11orf24; human.
DR GenomeRNAi; 53838; -.
DR Pharos; Q96F05; Tdark.
DR PRO; PR:Q96F05; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96F05; protein.
DR Bgee; ENSG00000171067; Expressed in right lobe of liver and 189 other tissues.
DR ExpressionAtlas; Q96F05; baseline and differential.
DR Genevisible; Q96F05; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR041056; DUF5585.
DR Pfam; PF17823; DUF5585; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Golgi apparatus; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..449
FT /note="Uncharacterized protein C11orf24"
FT /id="PRO_0000251887"
FT TOPO_DOM 21..400
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..449
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 72..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 97
FT /note="G -> V (in dbSNP:rs3802746)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:15498874"
FT /id="VAR_027713"
FT VARIANT 150
FT /note="A -> T (in dbSNP:rs901827)"
FT /id="VAR_027714"
SQ SEQUENCE 449 AA; 46101 MW; 11C8B0FCC3BBF921 CRC64;
MWTALVLIWI FSLSLSESHA ASNDPRNFVP NKMWKGLVKR NASVETVDNK TSEDVTMAAA
SPVTLTKGTS AAHLNSMEVT TEDTSRTDVS EPATSGGAAD GVTSIAPTAV ASSTTAASIT
TAASSMTVAS SAPTTAASST TVASIAPTTA ASSMTAASST PMTLALPAPT STSTGRTPST
TATGHPSLST ALAQVPKSSA LPRTATLATL ATRAQTVATT ANTSSPMSTR PSPSKHMPSD
TAASPVPPMR PQAQGPISQV SVDQPVVNTT NKSTPMPSNT TPEPAPTPTV VTTTKAQARE
PTASPVPVPH TSPIPEMEAM SPTTQPSPMP YTQRAAGPGT SQAPEQVETE ATPGTDSTGP
TPRSSGGTKM PATDSCQPST QGQYMVVTTE PLTQAVVDKT LLLVVLLLGV TLFITVLVLF
ALQAYESYKK KDYTQVDYLI NGMYADSEM
