CK024_MOUSE
ID CK024_MOUSE Reviewed; 392 AA.
AC Q9D8N1; Q8VCP2;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Uncharacterized protein C11orf24 homolog;
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000250}; Single-pass type I membrane protein
CC {ECO:0000250}. Note=Cycles to the plasma membrane via endosomes in a pH
CC sensitive manner. Associated with Rab6-positive vesicles (By
CC similarity). {ECO:0000250}.
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DR EMBL; AK007868; BAB25319.1; -; mRNA.
DR EMBL; AK154828; BAE32858.1; -; mRNA.
DR EMBL; BC019471; AAH19471.1; -; mRNA.
DR CCDS; CCDS50342.1; -.
DR RefSeq; NP_082353.1; NM_028077.2.
DR RefSeq; XP_006531903.1; XM_006531840.1.
DR RefSeq; XP_006531904.1; XM_006531841.2.
DR AlphaFoldDB; Q9D8N1; -.
DR SMR; Q9D8N1; -.
DR BioGRID; 215122; 3.
DR IntAct; Q9D8N1; 4.
DR STRING; 10090.ENSMUSP00000047063; -.
DR GlyConnect; 2811; 1 N-Linked glycan (1 site).
DR GlyGen; Q9D8N1; 3 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q9D8N1; -.
DR PhosphoSitePlus; Q9D8N1; -.
DR PaxDb; Q9D8N1; -.
DR PRIDE; Q9D8N1; -.
DR Antibodypedia; 2629; 71 antibodies from 17 providers.
DR DNASU; 72056; -.
DR Ensembl; ENSMUST00000039048; ENSMUSP00000047063; ENSMUSG00000035372.
DR Ensembl; ENSMUST00000235295; ENSMUSP00000157453; ENSMUSG00000035372.
DR Ensembl; ENSMUST00000235837; ENSMUSP00000158554; ENSMUSG00000035372.
DR Ensembl; ENSMUST00000237955; ENSMUSP00000158133; ENSMUSG00000035372.
DR GeneID; 72056; -.
DR KEGG; mmu:72056; -.
DR UCSC; uc008fwt.1; mouse.
DR MGI; MGI:1919306; 1810055G02Rik.
DR VEuPathDB; HostDB:ENSMUSG00000035372; -.
DR eggNOG; ENOG502RZBP; Eukaryota.
DR GeneTree; ENSGT00940000153377; -.
DR HOGENOM; CLU_056955_0_0_1; -.
DR InParanoid; Q9D8N1; -.
DR OMA; KMPATDS; -.
DR OrthoDB; 1528686at2759; -.
DR PhylomeDB; Q9D8N1; -.
DR TreeFam; TF336966; -.
DR BioGRID-ORCS; 72056; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q9D8N1; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9D8N1; protein.
DR Bgee; ENSMUSG00000035372; Expressed in epithelium of small intestine and 266 other tissues.
DR ExpressionAtlas; Q9D8N1; baseline and differential.
DR Genevisible; Q9D8N1; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR041056; DUF5585.
DR Pfam; PF17823; DUF5585; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Golgi apparatus; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..392
FT /note="Uncharacterized protein C11orf24 homolog"
FT /id="PRO_0000251888"
FT TOPO_DOM 24..342
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 364..392
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 83..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 18
FT /note="S -> T (in Ref. 2; AAH19471)"
FT /evidence="ECO:0000305"
FT CONFLICT 112
FT /note="V -> A (in Ref. 2; AAH19471)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 392 AA; 41095 MW; 6BBA958C73489874 CRC64;
MWTALVLVWI SSVLLPRSHM MSAEPRNIVT NKWPKAVNQS MLRDTVPRTD NTFTERTAIV
PPAPVTLTTE TWAATLNSTR VTAEVTTHGT NTSTPTTREG TTDRVTSRTL AVPTSSGPSS
AEQTRPTTIA GLPSLSTPHA EVPRTNASVS PRTAMAATVA PHTATLAAGT VNTSDPHTRT
PSPAKSTPTD TSSKNPIPTS GAQIQGTTVQ LTTDQPVHST AGRSALSPSN ATLEPTTTQV
QTKEPSASTV PARATSLSPD VDVISPTTQP SPTLPTQGTG GPGTLLTTEQ VGTKTTSGTA
SAGPTSRSSG DIKVPTTDSC QPSTQGQYLV TIDALTPSLV NKMLLLVVLL VGVTLFIAVL
VMFALQAYES YKKKDYTQVD YLINGMYADS EM
