CK052_HUMAN
ID CK052_HUMAN Reviewed; 123 AA.
AC Q96A22;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Uncharacterized protein C11orf52;
GN Name=C11orf52;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-23.
RC TISSUE=Gastric mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-23.
RC TISSUE=PNS, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-30 AND SER-62, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q96A22; Q96DM3: RMC1; NbExp=3; IntAct=EBI-6660701, EBI-2804848;
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DR EMBL; AK057948; BAB71620.1; -; mRNA.
DR EMBL; AP000907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC008501; AAH08501.1; -; mRNA.
DR EMBL; BC110872; AAI10873.1; -; mRNA.
DR CCDS; CCDS8353.1; -.
DR RefSeq; NP_542390.2; NM_080659.2.
DR AlphaFoldDB; Q96A22; -.
DR BioGRID; 124891; 310.
DR IntAct; Q96A22; 3.
DR STRING; 9606.ENSP00000278601; -.
DR iPTMnet; Q96A22; -.
DR PhosphoSitePlus; Q96A22; -.
DR BioMuta; C11orf52; -.
DR EPD; Q96A22; -.
DR jPOST; Q96A22; -.
DR MassIVE; Q96A22; -.
DR PaxDb; Q96A22; -.
DR PeptideAtlas; Q96A22; -.
DR PRIDE; Q96A22; -.
DR ProteomicsDB; 75893; -.
DR Antibodypedia; 51501; 24 antibodies from 10 providers.
DR DNASU; 91894; -.
DR Ensembl; ENST00000278601.6; ENSP00000278601.5; ENSG00000149300.10.
DR GeneID; 91894; -.
DR KEGG; hsa:91894; -.
DR MANE-Select; ENST00000278601.6; ENSP00000278601.5; NM_080659.3; NP_542390.2.
DR UCSC; uc058hgo.1; human.
DR CTD; 91894; -.
DR GeneCards; C11orf52; -.
DR HGNC; HGNC:30531; C11orf52.
DR HPA; ENSG00000149300; Low tissue specificity.
DR neXtProt; NX_Q96A22; -.
DR OpenTargets; ENSG00000149300; -.
DR PharmGKB; PA143485347; -.
DR VEuPathDB; HostDB:ENSG00000149300; -.
DR eggNOG; ENOG502S7WW; Eukaryota.
DR GeneTree; ENSGT00390000015195; -.
DR HOGENOM; CLU_1980817_0_0_1; -.
DR InParanoid; Q96A22; -.
DR OMA; ESNLHYA; -.
DR OrthoDB; 1424932at2759; -.
DR PhylomeDB; Q96A22; -.
DR TreeFam; TF336887; -.
DR PathwayCommons; Q96A22; -.
DR SignaLink; Q96A22; -.
DR BioGRID-ORCS; 91894; 6 hits in 1035 CRISPR screens.
DR GenomeRNAi; 91894; -.
DR Pharos; Q96A22; Tdark.
DR PRO; PR:Q96A22; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96A22; protein.
DR Bgee; ENSG00000149300; Expressed in adult mammalian kidney and 93 other tissues.
DR ExpressionAtlas; Q96A22; baseline and differential.
DR Genevisible; Q96A22; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR InterPro; IPR028106; DUF4578.
DR PANTHER; PTHR37342; PTHR37342; 1.
DR Pfam; PF15147; DUF4578; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..123
FT /note="Uncharacterized protein C11orf52"
FT /id="PRO_0000263609"
FT REGION 17..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 30
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 62
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VARIANT 23
FT /note="T -> R (in dbSNP:rs7124407)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_029587"
SQ SEQUENCE 123 AA; 13921 MW; 481C3A554E64B33D CRC64;
MGNRVCCGGS WSCPSTFQKK KKTGSQTRRT LKPQPQQLQQ NLPKGHETTG HTYERVLQQQ
GSQERSPGLM SEDSNLHYAD IQVCSRPHAR EVKHVHLENA TEYATLRFPQ ATPRYDSKNG
TLV
