ID   CK053_HUMAN             Reviewed;         288 AA.
AC   Q8IXP5; A0A1C7CYV6;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Protein POU2AF2;
DE   AltName: Full=POU class 2 homeobox-associating factor 2 {ECO:0000312|HGNC:HGNC:30527};
GN   Name=POU2AF2 {ECO:0000312|HGNC:HGNC:30527}; Synonyms=C11orf53;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-288.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=25048349;
RA   Delgado A.P., Brandao P., Chapado M.J., Hamid S., Narayanan R.;
RT   "Open reading frames associated with cancer in the dark matter of the human
RT   genome.";
RL   Cancer Genomics Proteomics 11:201-213(2014).
CC   -!- TISSUE SPECIFICITY: Detected in colorectal cancer.
CC       {ECO:0000269|PubMed:25048349}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH39669.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC039669; AAH39669.1; ALT_INIT; mRNA.
DR   EMBL; AP002448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_940900.1; NM_198498.2.
DR   RefSeq; XP_011541105.1; XM_011542803.2.
DR   RefSeq; XP_011541106.1; XM_011542804.2.
DR   AlphaFoldDB; Q8IXP5; -.
DR   SMR; Q8IXP5; -.
DR   BioGRID; 131113; 6.
DR   IntAct; Q8IXP5; 3.
DR   MINT; Q8IXP5; -.
DR   STRING; 9606.ENSP00000280325; -.
DR   iPTMnet; Q8IXP5; -.
DR   PhosphoSitePlus; Q8IXP5; -.
DR   BioMuta; C11orf53; -.
DR   DMDM; 74728218; -.
DR   PaxDb; Q8IXP5; -.
DR   PRIDE; Q8IXP5; -.
DR   Antibodypedia; 45588; 133 antibodies from 19 providers.
DR   DNASU; 341032; -.
DR   Ensembl; ENST00000637637.1; ENSP00000489630.1; ENSG00000150750.9.
DR   GeneID; 341032; -.
DR   KEGG; hsa:341032; -.
DR   MANE-Select; ENST00000280325.7; ENSP00000280325.6; NM_198498.3; NP_940900.2.
DR   UCSC; uc001plc.4; human.
DR   CTD; 341032; -.
DR   DisGeNET; 341032; -.
DR   GeneCards; C11orf53; -.
DR   HGNC; HGNC:30527; POU2AF2.
DR   HPA; ENSG00000150750; Tissue enhanced (stomach, testis).
DR   neXtProt; NX_Q8IXP5; -.
DR   OpenTargets; ENSG00000150750; -.
DR   PharmGKB; PA143485348; -.
DR   VEuPathDB; HostDB:ENSG00000150750; -.
DR   eggNOG; ENOG502RC2Q; Eukaryota.
DR   GeneTree; ENSGT00390000000586; -.
DR   HOGENOM; CLU_086232_0_0_1; -.
DR   InParanoid; Q8IXP5; -.
DR   OMA; LEDAHYH; -.
DR   OrthoDB; 1134997at2759; -.
DR   PhylomeDB; Q8IXP5; -.
DR   TreeFam; TF332345; -.
DR   PathwayCommons; Q8IXP5; -.
DR   SignaLink; Q8IXP5; -.
DR   BioGRID-ORCS; 341032; 15 hits in 1042 CRISPR screens.
DR   GenomeRNAi; 341032; -.
DR   Pharos; Q8IXP5; Tdark.
DR   PRO; PR:Q8IXP5; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8IXP5; protein.
DR   Bgee; ENSG00000150750; Expressed in mucosa of transverse colon and 64 other tissues.
DR   ExpressionAtlas; Q8IXP5; baseline and differential.
DR   Genevisible; Q8IXP5; HS.
DR   InterPro; IPR037655; C11orf53.
DR   PANTHER; PTHR28376; PTHR28376; 1.
DR   Pfam; PF17721; DUF5566; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..288
FT                   /note="Protein POU2AF2"
FT                   /id="PRO_0000263611"
FT   REGION          193..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   288 AA;  31101 MW;  90C3CF5F9F2F577A CRC64;
     MESVPGDYSK RVYQGVRVKH TVKDLLAEKR SGQTSNSRLN GSVSSSQSPF VQMPGSPVTS
     GYYGVRRSFL SDSDFHNSKQ FSNDVYTSSV GKPFPCESSA GQSHAALLEP YFPQEPYGDY
     RPPALTPNAG SLFSASPLPP LLPPPFPGDP AHFLFRDSWE QTLPDGLSQP DPVSADALLT
     LPPSTSCLSQ LESGSIAQHR GSSWGSSLAG AQSYSLHALE DLHHTPGYPT PPPYPFTPFM
     TVSNDLPPKV GPLSPDEEAD TGSLHDPSPW VKEDGSIAWG SYECRRAY