CK053_MOUSE
ID CK053_MOUSE Reviewed; 287 AA.
AC Q9D8Q6; A0A5K1VW51;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-AUG-2022, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Protein POU2AF2;
GN Name=Pou2af2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-287.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D8Q6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D8Q6-2; Sequence=VSP_061593;
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DR EMBL; AK007796; BAB25262.1; -; mRNA.
DR EMBL; AC160052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC122499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120857; AAI20858.1; -; mRNA.
DR EMBL; BC120859; AAI20860.1; -; mRNA.
DR CCDS; CCDS52792.1; -.
DR RefSeq; NP_081493.1; NM_027217.1.
DR RefSeq; XP_006510650.1; XM_006510587.1.
DR RefSeq; XP_006510651.1; XM_006510588.3.
DR RefSeq; XP_006510652.1; XM_006510589.3.
DR AlphaFoldDB; Q9D8Q6; -.
DR IntAct; Q9D8Q6; 1.
DR STRING; 10090.ENSMUSP00000036912; -.
DR PhosphoSitePlus; Q9D8Q6; -.
DR PaxDb; Q9D8Q6; -.
DR PRIDE; Q9D8Q6; -.
DR Antibodypedia; 45588; 133 antibodies from 19 providers.
DR Ensembl; ENSMUST00000039959; ENSMUSP00000036912; ENSMUSG00000036027.
DR Ensembl; ENSMUST00000181366; ENSMUSP00000137735; ENSMUSG00000036027.
DR GeneID; 69809; -.
DR KEGG; mmu:69809; -.
DR UCSC; uc009plh.2; mouse.
DR MGI; MGI:1917059; 1810046K07Rik.
DR VEuPathDB; HostDB:ENSMUSG00000036027; -.
DR eggNOG; ENOG502RC2Q; Eukaryota.
DR GeneTree; ENSGT00390000000586; -.
DR HOGENOM; CLU_086232_0_0_1; -.
DR InParanoid; Q9D8Q6; -.
DR OMA; LEDAHYH; -.
DR OrthoDB; 1134997at2759; -.
DR PhylomeDB; Q9D8Q6; -.
DR TreeFam; TF332345; -.
DR BioGRID-ORCS; 69809; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9D8Q6; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9D8Q6; protein.
DR Bgee; ENSMUSG00000036027; Expressed in small intestine Peyer's patch and 17 other tissues.
DR ExpressionAtlas; Q9D8Q6; baseline and differential.
DR Genevisible; Q9D8Q6; MM.
DR InterPro; IPR037655; C11orf53.
DR PANTHER; PTHR28376; PTHR28376; 1.
DR Pfam; PF17721; DUF5566; 1.
PE 2: Evidence at transcript level;
KW Alternative initiation; Reference proteome.
FT CHAIN 1..287
FT /note="Protein POU2AF2"
FT /id="PRO_0000263612"
FT REGION 109..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..52
FT /note="Missing (in isoform 2)"
FT /id="VSP_061593"
SQ SEQUENCE 287 AA; 31376 MW; 6CE8E1E177050F79 CRC64;
MDSVPRDYSK RVYQGVRVKH TVKDLLAEKR SRQTSNTRLN GSVSSSQPPF IQMPGSPVMS
GYYGVRRSFL SDSDFHSSKQ FSNDLYTSGM SKPFACESTA GQSHTGLLES YLAEPYGDYR
PPALTPTPSS LFSTSTLPPL LPPPFPSDPT HFVFRDSWEQ TVPDGLSQPD PMPADALQSL
PPSTSCLSQL ESGSSTQHRN MGWGASLAGA QSYSLHALED LHHTPGYPTS PPYPFTSFMT
VSNDLPPKVG PLSPEEGSDV SSLHDPSPWT KEDGSMAWGS YECRRAY
