CK054_MOUSE
ID CK054_MOUSE Reviewed; 315 AA.
AC Q91V76;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Ester hydrolase C11orf54 homolog;
DE EC=3.1.-.-;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Kidney, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J.,
RA Wiemann S., Schick M., Korn B.;
RT "Cloning of mouse full open reading frames in Gateway(R) system entry
RT vector (pDONR201).";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Exhibits ester hydrolase activity on the substrate p-
CC nitrophenyl acetate. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK088123; BAC40160.1; -; mRNA.
DR EMBL; AK147073; BAE27654.1; -; mRNA.
DR EMBL; CT010296; CAJ18504.1; -; mRNA.
DR EMBL; BC011540; AAH11540.1; -; mRNA.
DR EMBL; BC016078; AAH16078.1; -; mRNA.
DR CCDS; CCDS22835.1; -.
DR RefSeq; NP_001186413.1; NM_001199484.1.
DR RefSeq; NP_001186414.1; NM_001199485.1.
DR RefSeq; NP_598493.1; NM_133732.3.
DR RefSeq; XP_006510659.1; XM_006510596.2.
DR AlphaFoldDB; Q91V76; -.
DR SMR; Q91V76; -.
DR BioGRID; 214392; 3.
DR STRING; 10090.ENSMUSP00000136717; -.
DR iPTMnet; Q91V76; -.
DR PhosphoSitePlus; Q91V76; -.
DR SwissPalm; Q91V76; -.
DR EPD; Q91V76; -.
DR jPOST; Q91V76; -.
DR MaxQB; Q91V76; -.
DR PaxDb; Q91V76; -.
DR PeptideAtlas; Q91V76; -.
DR PRIDE; Q91V76; -.
DR Antibodypedia; 31588; 59 antibodies from 16 providers.
DR DNASU; 70984; -.
DR Ensembl; ENSMUST00000034414; ENSMUSP00000034414; ENSMUSG00000031938.
DR Ensembl; ENSMUST00000178977; ENSMUSP00000136335; ENSMUSG00000031938.
DR Ensembl; ENSMUST00000180339; ENSMUSP00000136717; ENSMUSG00000031938.
DR GeneID; 70984; -.
DR KEGG; mmu:70984; -.
DR UCSC; uc009ofm.2; mouse.
DR MGI; MGI:1918234; 4931406C07Rik.
DR VEuPathDB; HostDB:ENSMUSG00000031938; -.
DR eggNOG; KOG4048; Eukaryota.
DR GeneTree; ENSGT00390000017214; -.
DR HOGENOM; CLU_055541_0_0_1; -.
DR InParanoid; Q91V76; -.
DR OMA; HIMPDFS; -.
DR OrthoDB; 877242at2759; -.
DR PhylomeDB; Q91V76; -.
DR TreeFam; TF313169; -.
DR BioGRID-ORCS; 70984; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q91V76; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q91V76; protein.
DR Bgee; ENSMUSG00000031938; Expressed in parotid gland and 255 other tissues.
DR ExpressionAtlas; Q91V76; baseline and differential.
DR Genevisible; Q91V76; MM.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; ISO:MGI.
DR InterPro; IPR015021; DUF1907.
DR PANTHER; PTHR13204; PTHR13204; 1.
DR Pfam; PF08925; DUF1907; 1.
DR SMART; SM01168; DUF1907; 1.
PE 1: Evidence at protein level;
KW Hydrolase; Metal-binding; Nucleus; Reference proteome; Zinc.
FT CHAIN 1..315
FT /note="Ester hydrolase C11orf54 homolog"
FT /id="PRO_0000246030"
FT BINDING 266
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 268
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 278
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 315 AA; 34996 MW; 7F4B343E9EAAF50E CRC64;
MACSEFSFHM PSLEELAEVL QKGLTDNFAD VQVSVVDCPD LTKEPFTFPV RGICGQTRIA
EVGGVPYLLP LVNKKKVYDL NEIAKVIKLP GAFILGAGAG PFQTLGFNSE FMPIVQTASE
HNQPVNGSYF AHKNPADGAC LLEKYSQKYH DFGCALLANL FASEGQPGKV IEVQAKRRTG
ELNFVSCMRQ TLEEHYGDKP VGMGGTFIVQ KGKVKAHIMP AEFSSCPLNS DEAVNKWLHF
YEMKAPLVCL PVFVSKDPGL DLRLEHTHFF SHHGEGGHYH YDTTPDTVEY LGYFSPAQFL
YRIDQPKETH AFGRD
